Oncogenic transformation of C3H/10T1/2 cells by X-rays, fast-fission neutrons, and cyclotron-produced neutrons.
Oncogenic transformation of C3H/10T1/2 cells by X-rays, fast-fission neutrons, and cyclotron-produced neutrons.
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X 射线、快裂变中子和回旋加速器产生的中子对 C3H/10T1/2 细胞进行致癌转化。
DOI：
10.1080/09553008314551321
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
G. H. Harrison
中科院分区：
文献类型：
--
作者：
E. Balcer;G. H. Harrison
致死率和致癌性转化进行了测量，在C3 H/10 T1/2小鼠成纤维细胞暴露于中子和X-射线在0.5和11戈伊之间的剂量。用X射线和低能量反应堆产生的中子的变换结果被用作基线，以比较和评估用高能量回旋加速器产生的中子获得的结果。这些辐射是100千伏特X射线，每分钟0.49戈伊，反应堆裂变中子，每分钟0.10至0.31戈伊，伽马剂量成分为8%至20%，回旋加速器产生的中子，每分钟0.51戈伊，平均能量为38兆电子伏，伽马剂量成分为8%。放射生物学效应（r.b.e.）裂变中子的细胞致死率为2.4 +/- 0.2，高能中子的细胞致死率为1.7 +/- 0.1。对于X射线、裂变中子和回旋加速器产生的中子，每千个存活细胞中转化体的最大比例分别为3.7 +/- 0.8、6.5 +/- 0.7和2.3 +/- 0.6。最大观测r.b.e.裂变中子的相变感应系数为3.8，回旋中子的相变感应系数为1.2。因此，高能中子表现出更高的r.b.e.。在C3 H/10 T1/2细胞中，细胞杀伤能力高于致癌转化能力。
Lethality and oncogenic transformation were measured in C3H/10T1/2 murine fibroblasts exposed to neutrons and X-rays at doses between 0.5 and 11 Gy. Transformation results with X-rays and low-energy, reactor-produced neutrons were used as a baseline to compare and evaluate the results obtained with high-energy, cyclotron-produced neutrons. The radiations were 100-kVp X-rays at 0.49 Gy min-1, reactor fission neutrons at 0.10 to 0.31 Gy min-1 with an 8 to 20 per cent gamma dose component, and cyclotron-produced neutrons at 0.51 Gy min-1 with mean energy 38 MeV and an 8 per cent gamma dose component. The radiobiological effectiveness (r.b.e.) for cell lethality was 2.4 +/- 0.2 for fission neutrons and 1.7 +/- 0.1 for high-energy neutrons. The maximum proportions of transformants per thousand surviving cells were, respectively, 3.7 +/- 0.8, 6.5 +/- 0.7, and 2.3 +/- 0.6 for X-rays, fission neutrons, and cyclotron-produced neutrons. The maximum observed r.b.e. for transformation induction was 3.8 for fission neutrons and 1.2 for cyclotron neutrons. Thus, high-energy neutrons exhibit a higher r.b.e. for cell killing capacity than for oncogenic transformation in C3H/10T1/2 cells.
DOI：
10.1073/pnas.77.12.7262
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
KENNEDY, AR;FOX, M;LITTLE, JB
通讯作者：
LITTLE, JB