Effects of circadian disruption on methamphetamine consumption in methamphetamine-exposed rats.
Effects of circadian disruption on methamphetamine consumption in methamphetamine-exposed rats.
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DOI：
10.1007/s00213-014-3845-2
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发表时间：
2015-06
影响因子：
3.4
通讯作者：
Lynch, Wendy J.
中科院分区：
文献类型：
--
作者：
Doyle, Susan E.;Feng, Hanting;Garber, Garrett;Menaker, Michael;Lynch, Wendy J.
大量的临床研究表明睡眠异常和药物滥用之间的关联;然而，昼夜节律系统在成瘾发展中所起的作用在很大程度上是未知的。本研究的目的是检查实验诱导的慢性时差对甲基苯丙胺的大鼠模型中的甲基苯丙胺消耗的影响。将雄性Sprague-Dawley大鼠（n=32）以12：12光：暗循环饲养在转轮笼中。一组大鼠（n=16）被给予两周的强制甲基苯丙胺消费（0.01%的饮用水;甲基预先暴露），而第二组（n=16，未预先暴露）只接受水。随后是两周的禁欲期，在此期间，每组中的一半动物暴露于4个连续的6小时提前的光：暗周期相移，而另一半保持在原始的光：暗周期。甲基苯丙胺的消费进行了评估，在所有的大鼠剥夺期后，使用两瓶的选择范例。甲基苯丙胺的消费量最初低于甲基苯丙胺预暴露与未预暴露的大鼠。然而，在禁欲后的第二周，消费量显着较高的相移大鼠的甲基苯丙胺预暴露组相比，所有其他组。这些数据揭示了昼夜节律紊乱对甲基苯丙胺消费的影响，并建议在复发和成瘾的病因学中考虑昼夜节律系统的失调。
A substantial number of clinical studies indicate associations between sleep abnormalities and drug abuse; however, the role played by the circadian system in the development of addiction is largely unknown. The aim of this study was to examine the effects of experimentally induced chronic jet lag on methamphetamine consumption in a rat model of methamphetamine drinking. Male Sprague-Dawley rats (n=32) were housed in running wheel cages in a 12:12 light:dark cycle. One group of rats (n=16) was given two weeks of forced methamphetamine consumption (0.01% in drinking water; meth pre-exposed) while a second group (n=16, not pre-exposed) received water only. This was followed by a two week abstinence period during which half of the animals from each group were exposed to 4 consecutive 6-hr advancing phase shifts of the light:dark cycle, while the other half remained on the original light:dark cycle. Methamphetamine consumption was assessed in all rats following the deprivation period using a two-bottle choice paradigm. Methamphetamine consumption was initially lower in methamphetamine pre-exposed vs. not pre-exposed rats. However, during the second week following abstinence, consumption was significantly higher in phase shifted rats of the methamphetamine pre-exposed group compared to all other groups. These data reveal an effect of circadian rhythm disturbance on methamphetamine consumption, and suggest that dysregulation of the circadian system be considered in the etiology of relapse and addiction.
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DOI：
10.1097/01.alc.0000081622.03973.57
发表时间：
2003-08-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Currie, SR;Clark, S;Malhotra, S
通讯作者：
Malhotra, S
影响因子：
4.7
作者：
Falcón E;McClung CA
通讯作者：
McClung CA
DOI：
10.4049/jimmunol.1001026
发表时间：
2010-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castanon-Cervantes O;Wu M;Ehlen JC;Paul K;Gamble KL;Johnson RL;Besing RC;Menaker M;Gewirtz AT;Davidson AJ
通讯作者：
Davidson AJ
影响因子：
4.9
作者：
Karlsson, B;Knutsson, A;Lindahl, B
通讯作者：
Lindahl, B
影响因子：
2.8
作者：
Iwamoto, Ayaka;Kawai, Misato;Yasuo, Shinobu
通讯作者：
Yasuo, Shinobu