Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells.
Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells.
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DOI：
10.1016/j.clim.2008.08.030
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Markovic-Plese S
中科院分区：
文献类型：
--
作者：
Montes M;Zhang X;Berthelot L;Laplaud DA;Brouard S;Jin J;Rogan S;Armao D;Jewells V;Soulillou JP;Markovic-Plese S
In this study, acute and chronic brain and spinal cord lesions, and normal appearing white matter (NAWM), were resected post-mortem from a patient with aggressive relapsing-remitting multiple sclerosis (MS). T-cell infiltrates from the central nervous system (CNS) lesions and NAWM were separated and characterized in-vitro. All infiltrates showed a proliferative response against multiple myelin peptides. Studies of the T-cell receptor (TCR)Vβ and Jβ usage revealed a very skewed repertoire with shared complementarity-determining region (CDR)3 lengths detected in all CNS lesions and NAWM. In the acute lesion, genomic profiling of the infiltrating T-cells revealed up-regulated expression of TCRα and β chain, retinoic acid-related orphan nuclear hormone receptor C (RORC) transcription factor, and multiple cytokine genes that mediate Th17 cell expansion. The differentially expressed genes involved in regulation of Th17 cells represent promising targets for new therapies of relapsing-remitting MS.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
9.9
作者：
Wingerchuk, D. M.;Lennon, V. A.;Weinshenker, B. G.
通讯作者：
Weinshenker, B. G.
DOI：
10.1073/pnas.0600666103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Chen, Zhi;Laurence, Arian;O'Shea, John J.
通讯作者：
O'Shea, John J.
影响因子：
3.3
作者：
Muraro, PA;Cassiani-Ingoni, R;Martin, R
通讯作者：
Martin, R
影响因子：
4.4
作者：
Ponomarev, ED;Dittel, BN
通讯作者：
Dittel, BN