Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China.
Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China.
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中国武汉近一千万居民的锁骨后SARS-COV-2核酸筛查。
DOI：
10.1038/s41467-020-19802-w
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发表时间：
2020-11-20
影响因子：
16.6
通讯作者：
Lu Z
中科院分区：
文献类型：
--
作者：
Cao S;Gan Y;Wang C;Bachmann M;Wei S;Gong J;Huang Y;Wang T;Li L;Lu K;Jiang H;Gong Y;Xu H;Shen X;Tian Q;Lv C;Song F;Yin X;Lu Z
于二零二零年一月二十三日至四月八日期间，武汉实施严格的COVID-19控制措施。对解除限制后的感染流行率的估计可为封锁后的大流行病管理提供信息。在这里，我们描述了2020年5月14日至6月1日在武汉进行的全市SARS-CoV-2核酸筛查计划。所有六岁或六岁以上的城市居民都有资格参加，9，899，828人（92.9%）参加。未发现新增有症状病例，无症状病例300例（检出率0.303/10000，95%CI 0.270-0.339/10000）。无症状病例的1,174名密切接触者中无阳性检测。34，424名既往治愈的COVID-19患者中有107人再次检测阳性（再阳性率为0.31%，95%CI 0.423-0.574%）。因此，在封城结束后5至8周，武汉的SARS-CoV-2感染率非常低。大规模的人群筛查可以提供对正在进行的SARS-CoV-2传播水平的见解。在这里，作者报告了对武汉约10，000，000名居民的全市筛查，并显示SARS-CoV-2感染率在封锁结束后5至8周非常低。
Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (detection rate 0.303/10,000, 95% CI 0.270–0.339/10,000) were identified. There were no positive tests amongst 1,174 close contacts of asymptomatic cases. 107 of 34,424 previously recovered COVID-19 patients tested positive again (re-positive rate 0.31%, 95% CI 0.423–0.574%). The prevalence of SARS-CoV-2 infection in Wuhan was therefore very low five to eight weeks after the end of lockdown. Large-scale population screening can provide insights to levels of ongoing SARS-CoV-2 transmission. Here, the authors report a citywide screening of ~10,000,000 residents of Wuhan and show that SARS-CoV-2 infection prevalence was very low five to eight weeks after the end of lockdown.
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