Prenatal cocaine exposure affects the development of aortic adrenergic innervation and contractile responses.
Prenatal cocaine exposure affects the development of aortic adrenergic innervation and contractile responses.
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产前接触可卡因会影响主动脉肾上腺素能神经支配和收缩反应的发育。
DOI：
10.1016/0024-3205(94)00765-9
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发表时间：
1994
期刊：
影响因子：
6.1
通讯作者：
Roberts,J
中科院分区：
文献类型：
--
作者：
Johnson,MD;Gurdal,H;Cai,G;Snyder,DL;Roberts,J
本研究探讨了产前可卡因管理血管交感神经支配和收缩反应的发展的影响。家兔在妊娠第8 - 29天接受可卡因（4 mg/kg，iv，bid）或生理盐水。在出生后第10、20、30和50天获得主动脉。通过测量主动脉对去甲肾上腺素（NE）和其他血管收缩剂的收缩反应来评估血管平滑肌反应性。血管肾上腺素能神经支配通过测量地昔帕明敏感的[3 H]-NE摄取到主动脉环段和主动脉NE含量来评价。[~ 3 H]-NE摄取和NE含量在出生后10和20天在产前暴露于可卡因的兔子减少。在出生后第30或50天未观察到差异。产前暴露于可卡因的家兔对NE的收缩反应降低。最大反应和效力在出生后第10天降低，效力在第20天仍然降低，但在年龄较大时没有降低。对5-羟色胺（5-HT）和血管紧张素II（AII）的收缩反应不受产前可卡因暴露的影响。这些结果表明，产前可卡因暴露会延迟主动脉肾上腺素能神经支配和α肾上腺素受体反应性的发展。
This study examines the effects of prenatal cocaine administration on the development of vascular sympathetic innervation and contractile responsiveness. Rabbits received cocaine (4 mg/kg, iv, bid) or saline during gestational days 8 to 29. Aortas were obtained on postnatal days 10, 20, 30 and 50. Vascular smooth muscle responsiveness was assessed by measuring aortic contractile responses to norepinephrine (NE) and to other vasoconstrictors. Vascular adrenergic innervation was evaluated by measuring desipramine sensitive [3H]-NE uptake into aortic ring segments and aortic NE content. [3H]-NE uptake and NE content were reduced at postnatal days 10 and 20 in the rabbits exposed prenatally to cocaine. Differences were not observed at postnatal days 30 or 50. The contractile response to NE was reduced in rabbits exposed to cocaine prenatally. Maximal response and potency were decreased at postnatal day 10 and potency was still decreased at day 20, but not at the older ages. Contractile responses to serotonin (5-HT) and angiotensin II (AII) were not affected by prenatal cocaine exposure. These results suggest that prenatal cocaine exposure delays the development of aortic adrenergic innervation and alpha adrenoceptor responsiveness.
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DOI：
--
发表时间：
1971
期刊：
Life sciences. Pt. 1: Physiology and pharmacology
影响因子：
--
作者：
R. Bevan
通讯作者：
R. Bevan
年龄对心脏交感神经效应器连接处神经传递的影响。
DOI：
--
发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Daly,RN;Goldberg,PB;Roberts,J
通讯作者：
Roberts,J
影响因子：
2.9
作者：
ANDERSONBROWN, T;SLOTKIN, TA;SEIDLER, FJ
通讯作者：
SEIDLER, FJ
6-羟基多巴胺诱导的去甲肾上腺素耗竭对小脑发育的影响。
影响因子：
2.9
作者：
K. Lovell
通讯作者：
K. Lovell
DOI：
--
发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Slotkin,TA;Levant,B;Orband-Miller,L;Queen,KL;Stasheff,S
通讯作者：
Stasheff,S