Kidney immunology: embracing the complexity to advance the field.
Kidney immunology: embracing the complexity to advance the field.
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DOI：
10.1093/ckj/sfab222
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发表时间：
2022-03
影响因子：
4.6
通讯作者：
Cravedi P
中科院分区：
文献类型：
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作者：
Riella LV;Cravedi P
几乎所有肾脏疾病的病理生理学都涉及免疫异常[1]，尿毒症本身对免疫系统有重大影响[2]。尽管如此，目前对与不同肾脏疾病相关的特定免疫异常的了解还相当初级。类固醇、烷化剂和钙调神经磷酸酶抑制剂一直是大多数肾小球疾病的主要治疗方法，尽管它们的免疫机制不同[3]。这种简单化的治疗态度最初是由有限的治疗选择推动的。然而，由于缺乏对单个肾小球疾病的免疫发病机制的了解，包括特定的免疫细胞和分子通路，生物制剂的可获得性提供了许多新的治疗方法，这些治疗方法尚未整合到肾病学家的医疗设备中。
Abnormal immunity is involved in the pathophysiology of virtually any renal disease [1] and uremia per se has a significant impact on the immune system [2]. Nonetheless, the current understanding of specific immune abnormalities associated with different kidney diseases is quite rudimentary. This is responsible, at least in part, for the absence of specific treatments for most of these conditions.Steroids, alkylating agents and calcineurin inhibitors have been the main treatments for most glomerular diseases, despite their different immune pathogenesis [3]. This simplistic treatment attitude was initially driven by the limited therapeutic options. However, the availability of biologics has offered numerous novel treatments that have not been integrated in the armamentarium of the nephrologists due to a lack of knowledge of the immune pathogenesis in individual glomerular diseases, including specific immune cells and molecular pathways that should be targeted.
影响因子：
3.9
作者：
Betjes MGH
通讯作者：
Betjes MGH
影响因子：
82.9
作者：
通讯作者：
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