Ambient air pollution and hypertensive disorder of pregnancy.
Ambient air pollution and hypertensive disorder of pregnancy.
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DOI：
10.1136/jech-2013-202902
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发表时间：
2014-01
影响因子：
6.3
通讯作者：
Roth J
中科院分区：
文献类型：
--
作者：
Xu X;Hu H;Ha S;Roth J
环境空气污染与妊娠期高血压疾病（HDP）的发生有关。然而，空气污染和HDP之间的关联的证据仍然是有限的，气体空气污染物对HDP的影响和暴露的时间窗口还没有得到很好的研究。我们使用佛罗里达出生登记数据，调查空气污染物（NO2，SO2，PM2.5，O3和CO）和HDP的风险之间的关系，在杰克逊维尔，佛罗里达，美国从2004年至2005年的22 041名孕妇。此外，我们还研究了在孕期和整个妊娠期定义的不同时间窗内的空气污染暴露是否对HDP有不同的影响。单污染物logistic回归模型显示，在调整协变量后，整个妊娠期暴露于四种污染物与HDP患病率显著相关：NO2（OR=1.21，95% CI 1.09 - 1.35）、PM2.5（OR=1.24，95% CI 1.08 - 1.43）、SO2（OR=1.13，95% CI 1.01 - 1.25）和CO（OR=1.12，95% CI 1.03 - 1.22）/IQR增加。当第一个三个月暴露于NO2，SO2和CO，和第二个三个月暴露于PM2.5进行了检查，观察到类似的效果。在多污染物模型中得到了一致的结果。这项研究表明，在美国佛罗里达，妊娠早期和整个妊娠期暴露于高水平的空气污染与HDP的患病率增加有关。
Ambient air pollution has been implicated in the development of hypertensive disorders of pregnancy (HDP). However, evidence of the association between air pollution and HDP is still limited, and the effects of gaseous air pollutants on HDP and their time windows of exposure have not been well studied. We used the Florida birth registry data to investigate the associations between air pollutants (NO2, SO2, PM2.5, O3 and CO) and the risks of HDP in 22 041 pregnant women in Jacksonville, Florida, USA from 2004 to 2005. Further, we examined whether air pollution exposure during different time windows defined by trimesters and the entire pregnancy had different effects on HDP. The single-pollutant logistic regression model showed that exposure to four pollutants during the full pregnancy period was significantly associated with prevalence of HDP after adjusting for covariates: NO2 (OR=1.21, 95% CI 1.09 to 1.35), PM2.5 (OR=1.24, 95% CI 1.08 to 1.43), SO2 (OR=1.13, 95% CI 1.01 to 1.25) and CO (OR=1.12, 95% CI 1.03 to 1.22) per IQR increase. Similar effects were observed when first trimester exposure to NO2, SO2 and CO, and second trimester exposures to PM2.5 were examined. Consistent results were confirmed in multiple-pollutant models. This study suggests that exposure to high levels of air pollution during early pregnancy and the full gestational period was associated with increased prevalence of HDP in Florida, USA.
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DOI：
10.1097/ede.0b013e31824523f0
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bind MA;Baccarelli A;Zanobetti A;Tarantini L;Suh H;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
10.4
作者：
Allen RW;Adar SD;Avol E;Cohen M;Curl CL;Larson T;Liu LJ;Sheppard L;Kaufman JD
通讯作者：
Kaufman JD
影响因子：
2.8
作者：
Basile, Jan N.;Bloch, Michael J.
通讯作者：
Bloch, Michael J.
影响因子：
8.3
作者：
Ayala, DE;Hermida, RC;Iglesias, M
通讯作者：
Iglesias, M
影响因子：
3.1
作者：
Allen, Victoria M;Joseph, KS;Ohlsson, Arne
通讯作者：
Ohlsson, Arne