Limited preventive effect of prednisone on neuropsychiatric symptoms in murine systemic lupus erythematosus
Limited preventive effect of prednisone on neuropsychiatric symptoms in murine systemic lupus erythematosus
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泼尼松对小鼠系统性红斑狼疮神经精神症状的预防作用有限
DOI：
10.1007/s10787-019-00587-4
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发表时间：
2019-03
影响因子：
5.8
通讯作者：
Xu Zhenghao
中科院分区：
文献类型：
--
作者：
Lu Feilong;Lu Haimei;Xie Meijuan;Li Shan;Zu Yunyun;Zhou Jia;Yu Jie;Wang Shuang;Ruan Yeping;Wen Chengping;Xu Zhenghao
ObjectiveTo investigate whether glucocorticoids, the hallmark medication for systemic lupus erythematosus (SLE), could prevent the development of neuropsychiatric SLE (NPSLE).MethodsThe protective effects of prednisone on NPSLE were tested using the open field, object recognition/placement, forced swim, tail suspension, and sucrose preference tests in MRL/lpr mice. Auto-antibody titres and the weight of lymph nodes were also measured.ResultsMRL/lpr mice exhibited mild depression at the age of 8 weeks before progressing with spatial cognitive impairment and severe depression-like behaviour at the age of 16 weeks. Treating MRL/lpr mice with prednisone (5 mg/kg) from the age of 8 weeks decreased anti-cardiolipin and anti-N-methyl-d-aspartate (NMDA) receptor antibody titres in the brain, reduced the weight of lymph nodes, and prolonged the floating latency in the forced swim test. However, prednisone (3 or 5 mg/kg) had no preventive effect on the development of spatial cognitive impairment and other depression-like behaviours in MRL/lpr mice. The dose of prednisone had a positive correlation with the floating latency in the forced swim test, while it offered no effects on all other behavioural tests.ConclusionOur results provide evidence that early treatment with prednisone had a limited effect on the development of neuropsychiatric symptoms in MRL/lpr mice. Further work is needed in other models beyond NPSLE in MRL/lpr mice before any definitive conclusions are made on the efficacy of prednisone in human NPSLE.
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影响因子：
11.1
作者：
Xu, Zhenghao;Wang, Yi;Chen, Bin;Xu, Cenglin;Wu, Xiaohua;Wang, Ying;Zhang, Shihong;Hu, Weiwei;Wang, Shuang;Guo, Yi;Zhang, Xiangnan;Luo, Jianhong;Duan, Shumin;Chen, Zhong
通讯作者：
Chen, Zhong
影响因子：
7.3
作者：
Ehrenreich H
通讯作者：
Ehrenreich H
DOI：
10.1016/s0140-6736(01)05732-4
发表时间：
2001-08
期刊：
The Lancet
影响因子：
--
作者：
P. Stratta;C. Canavese;S. Santi;G. Ciccone;S. Rosso
通讯作者：
P. Stratta;C. Canavese;S. Santi;G. Ciccone;S. Rosso
影响因子：
11.5
作者：
Magro-Checa C;Zirkzee EJ;Huizinga TW;Steup-Beekman GM
通讯作者：
Steup-Beekman GM
影响因子：
9.3
作者：
Stock AD;Wen J;Doerner J;Herlitz LC;Gulinello M;Putterman C
通讯作者：
Putterman C