Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.
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DOI：
10.1371/journal.pone.0047934
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Salamone JD
中科院分区：
文献类型：
--
作者：
Randall PA;Pardo M;Nunes EJ;López Cruz L;Vemuri VK;Makriyannis A;Baqi Y;Müller CE;Correa M;Salamone JD
Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and instead select less effortful food-seeking behaviors. In the present study, the effects of several drug treatments were assessed using a progressive ratio (PROG)/chow feeding concurrent choice task. With this task, rats can lever press on a PROG schedule reinforced by a preferred high-carbohydrate food pellet, or alternatively approach and consume the less-preferred but concurrently available laboratory chow. Rats pass through each ratio level 15 times, after which the ratio requirement is incremented by one additional response. The DA D2 antagonist haloperidol (0.025–0.1 mg/kg) reduced number of lever presses and highest ratio achieved but did not reduce chow intake. In contrast, the adenosine A2A antagonist MSX-3 increased lever presses and highest ratio achieved, but decreased chow consumption. The cannabinoid CB1 inverse agonist and putative appetite suppressant AM251 decreased lever presses, highest ratio achieved, and chow intake; this effect was similar to that produced by pre-feeding. Furthermore, DA-related signal transduction activity (pDARPP-32(Thr34) expression) was greater in nucleus accumbens core of high responders (rats with high lever pressing output) compared to low responders. Thus, the effects of DA antagonism differed greatly from those produced by pre-feeding or reduced CB1 transmission, and it appears unlikely that haloperidol reduces PROG responding because of a general reduction in primary food motivation or the unconditioned reinforcing properties of food. Furthermore, accumbens core signal transduction activity is related to individual differences in work output.
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影响因子：
1.9
作者：
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通讯作者：
Green, Leonard
影响因子：
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作者：
Beeler JA;Frazier CR;Zhuang X
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从营养中取消的味道无法维持食物的增强特性。
DOI：
10.1111/j.1460-9568.2012.08167.x
发表时间：
2012-08
期刊：
The European journal of neuroscience
影响因子：
--
作者：
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通讯作者：
Zhuang X
DOI：
10.1111/j.1460-9568.2011.07916.x
发表时间：
2012-01
期刊：
The European journal of neuroscience
影响因子：
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作者：
Beeler JA;Frazier CR;Zhuang X
通讯作者：
Zhuang X
影响因子：
4.1
作者：
Ferré, S;Ciruela, F;Woods, A
通讯作者：
Woods, A