Dopamine modulates effort-based decision making in rats.
Dopamine modulates effort-based decision making in rats.
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DOI：
10.1037/a0014625
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发表时间：
2009-04
影响因子：
1.9
通讯作者：
Green, Leonard
中科院分区：
文献类型：
--
作者：
Bardgett, Mark E.;Depenbrock, Melissa;Downs, Nathan;Points, Megan;Green, Leonard
先前的研究表明，多巴胺是基于努力的选择行为的调节因素。本研究的目的是确定不同的多巴胺受体对大鼠基于努力的决策的个体贡献。老鼠在T型迷宫中被训练选择一个包含八粒食物的大奖励手臂，而不是一个包含两粒食物的小奖励手臂。然后，训练大鼠逐步爬上更高的障碍，以获得食物的大reward arm. Using在每个测试日的折扣程序，发现大鼠更有可能选择小reward手臂后，与D1拮抗剂，SCH-23390，或D2拮抗剂，氟哌啶醇治疗。多巴胺激动剂D-安非他明使大鼠偏向于选择大奖励组，并减弱了SCH-23390或氟哌啶醇的作用。用D3受体拮抗剂U99194或D3受体激动剂7-OH-DPAT治疗，没有改变选择行为。这些数据表明，D1和D2受体是基于努力的决策所必需的。
Previous research has implicated dopamine as a modulating factor in choice behavior based on effort. The purpose of the present study was to determine the individual contribution of different dopamine receptors to effort-based decision-making in rats. Rats were trained in a T-maze to choose a large-reward arm that contained eight pellets of food over a small-reward arm that contained two pellets of food. The rats then were trained to climb progressively higher barriers in order to obtain the food from the large-reward arm. Using a discounting procedure on each test day, it was found that rats were more likely to choose the small-reward arm after treatment with the D1 antagonist, SCH-23390, or the D2 antagonist, haloperidol. The dopamine agonist, D-amphetamine, biased the rats towards choosing the large-reward arm and blunted the effects of SCH-23390 or haloperidol. Treatment with the D3 receptor antagonist, U99194, or the D3 receptor agonist, 7-OH-DPAT, did not alter choice behavior. These data indicate that D1 and D2 receptors are required for decisions based on effort.
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影响因子：
2.7
作者：
Richards, JB;Mitchell, SH;Seiden, LS
通讯作者：
Seiden, LS
影响因子：
3.3
作者：
Bardgett, ME;Henry, JD
通讯作者：
Henry, JD
DOI：
10.3109/10401239409148986
发表时间：
1994-06-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Meador-Woodruff, J H
通讯作者：
Meador-Woodruff, J H
影响因子：
3.4
作者：
Bardgett, ME;Jackson, JL;Csernansky, JG
通讯作者：
Csernansky, JG
影响因子：
7.6
作者：
Pritchard, LM;Logue, AD;Richtand, NM
通讯作者：
Richtand, NM