A Unique Population: Adipose-Resident Regulatory T Cells.
A Unique Population: Adipose-Resident Regulatory T Cells.
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独特的群体：脂肪驻留的调节性 T 细胞。
DOI：
10.3389/fimmu.2018.02075
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发表时间：
2018
影响因子：
7.3
通讯作者：
Deng T
中科院分区：
文献类型：
--
作者：
Zeng Q;Sun X;Xiao L;Xie Z;Bettini M;Deng T
调节性T(Treg)细胞在健康和疾病的多种组织中具有抗炎功能。因此，居住在脂肪组织中的Treg细胞表现出特定的表型。它们的数量受年龄、性别和环境因素的影响，如饮食和寒冷刺激。脂肪驻留的Treg细胞被认为是脂肪组织免疫和代谢微环境的重要调节细胞，并参与肥胖相关代谢紊乱的发病机制。该综述综述了有关脂肪驻留的Treg细胞的现有信息。我们首先描述脂肪驻留的Treg细胞的起源、表型和功能。然后我们描述了脂肪驻留的Treg细胞的主要调节因子，并讨论了脂肪驻留的Treg细胞如何在瘦和肥胖的条件下被调节，特别是在人类中。最后，我们强调了它们在肥胖相关疾病中的治疗潜力。
Regulatory T (Treg) cell is well known for its anti-inflammatory function in a variety of tissues in health and disease. Accordingly, Treg cells that reside in adipose tissue exhibit specific phenotypes. Their numbers are regulated by age, gender and environmental factors, such as diet and cold stimulation. Adipose-resident Treg cells have been suggested to be critical regulators of immune and metabolic microenvironment in adipose tissue, as well as involved in pathogenesis of obesity-related metabolic disorders. This review surveys existing information on adipose-resident Treg cells. We first describe the origin, phenotype and function of adipose-resident Treg cells. We then describe the major regulators of adipose-resident Treg cells, and discuss how the adipose-resident Treg cells are regulated in lean and obese conditions, especially in humans. Finally, we highlight their therapeutic potential in obesity-related disorders.
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影响因子：
29
作者：
Deng T;Lyon CJ;Minze LJ;Lin J;Zou J;Liu JZ;Ren Y;Yin Z;Hamilton DJ;Reardon PR;Sherman V;Wang HY;Phillips KJ;Webb P;Wong ST;Wang RF;Hsueh WA
通讯作者：
Hsueh WA
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
16.6
作者：
Deng T;Liu J;Deng Y;Minze L;Xiao X;Wright V;Yu R;Li XC;Blaszczak A;Bergin S;DiSilvestro D;Judd R;Bradley D;Caligiuri M;Lyon CJ;Hsueh WA
通讯作者：
Hsueh WA
影响因子：
6
作者：
Baekkevold, ES;Roussigné, M;Girard, JP
通讯作者：
Girard, JP
影响因子：
3.7
作者：
Deiuliis J;Shah Z;Shah N;Needleman B;Mikami D;Narula V;Perry K;Hazey J;Kampfrath T;Kollengode M;Sun Q;Satoskar AR;Lumeng C;Moffatt-Bruce S;Rajagopalan S
通讯作者：
Rajagopalan S