Metabolic dysfunction and inflammatory disease: the role of stromal fibroblasts.
Metabolic dysfunction and inflammatory disease: the role of stromal fibroblasts.
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DOI：
10.1111/febs.15644
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Jones SW
中科院分区：
文献类型：
--
作者：
Farah H;Young SP;Mauro C;Jones SW
基质成纤维细胞是慢性炎症性疾病的中心介质。成纤维细胞代谢（包括糖酵解、氧化磷酸化、戊糖磷酸途径、谷氨酰胺代谢和乳酸转运）的变化促进并支持成纤维细胞表型向驱动慢性炎症的炎症活化表型的转变。癌症相关成纤维细胞驱动肿瘤进展，活化的滑膜细胞驱动关节炎症，活化的成肌细胞驱动纤维化疾病，包括慢性肾脏疾病，肺纤维化，心脏病和肝病。 间充质基质成纤维细胞已成为炎症反应的关键介质和局部炎症的驱动因素，部分原因是它们与炎症部位的驻留和循环免疫细胞相互作用。因此，它们与许多慢性炎症性疾病以及通过改变微环境而导致的肿瘤进展有关。炎症微环境中成纤维细胞的代谢变化和表型改变之间的联系，对于我们理解慢性炎症是如何调节的以及新的抗炎疗法的开发具有明确的意义。在这篇综述中，我们认为成纤维细胞代谢状态的变化是慢性炎症的基础。我们研究了最近关于炎症微环境中成纤维细胞代谢的研究，并考虑了它们参与炎症，从而深入了解成纤维细胞和代谢在介导炎症疾病进展中的作用，即癌症，关节炎和纤维化疾病，包括慢性肾脏疾病，肺纤维化，心脏病和肝脏疾病。
Stromal fibroblasts are central mediators of chronic inflammatory disease. Changes to fibroblast metabolism (including glycolysis, oxidative phosphorylation, pentose phosphate pathway, glutamine metabolism and lactate transport) fuels and underpins the switch in fibroblast phenotype towards an inflammatory‐activated phenotype that drives chronic inflammation. Cancer‐associated fibroblasts drive tumour progression, activated synoviocytes drive joint inflammation, and activated myoblasts drive fibrotic disorders including chronic kidney disease, pulmonary fibrosis, heart disease and liver disease. Mesenchymal stromal fibroblasts have emerged as key mediators of the inflammatory response and drivers of localised inflammation, in part through their interactions with resident and circulating immune cells at inflammatory sites. As such, they have been implicated in a number of chronic inflammatory conditions as well as in tumour progression through modifying the microenvironment. The connection between metabolic changes and altered phenotype of fibroblasts in inflammatory microenvironments has clear implications for our understanding of how chronic inflammation is regulated and for the development of new anti‐inflammatory therapeutics. In this review, we consider the evidence that changes to fibroblast metabolic state underpin chronic inflammation. We examine recent research on fibroblast metabolism in inflammatory microenvironments and consider their involvement in inflammation, providing insight into the role of fibroblasts and metabolism in mediating inflammatory disease progression namely cancer, arthritis and fibrotic disorders including chronic kidney disease, pulmonary fibrosis, heart disease and liver disease.
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影响因子：
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DOI：
10.1083/jcb.201704053
发表时间：
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影响因子：
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DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
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期刊：
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影响因子：
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作者：
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