Use of mouse models to study the mechanisms and consequences of RBC clearance.

Use of mouse models to study the mechanisms and consequences of RBC clearance.
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DOI:
10.1111/j.1423-0410.2010.01327.x
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发表时间:
2010-08-01
期刊:
影响因子:
2.7
通讯作者:
Spitalnik SL
Spitalnik SL
中科院分区:
医学4区
文献类型:
--
作者:
Hod EA;Arinsburg SA;Francis RO;Hendrickson JE;Zimring JC;Spitalnik SL

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Mice provide tractable animal models for studying the pathophysiology of various human disorders. This review discusses the use of mouse models for understanding red-blood-cell (RBC) clearance. These models provide important insights into the pathophysiology of various clinically relevant entities, such as autoimmune haemolytic anaemia, haemolytic transfusion reactions, other complications of RBC transfusions and immunomodulation by Rh immune globulin therapy. Mouse models of both antibody- and non-antibody-mediated RBC clearance are reviewed. Approaches for exploring unanswered questions in transfusion medicine using these models are also discussed.
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