Drug repurposing for the treatment of glioblastoma multiforme.
Drug repurposing for the treatment of glioblastoma multiforme.
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DOI：
10.1186/s13046-017-0642-x
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发表时间：
2017-11-28
期刊：
影响因子：
--
通讯作者：
Paggi MG
中科院分区：
文献类型：
--
作者：
Abbruzzese C;Matteoni S;Signore M;Cardone L;Nath K;Glickson JD;Paggi MG
多形性胶质母细胞瘤是最致命的脑肿瘤类型，其特点是预后非常差，总存活率有限。目前的最佳治疗方法十多年来基本保持不变，包括最大限度的手术切除，然后是放射治疗加替莫唑胺。如此令人沮丧的患者结果表明，迫切需要创新和有效的治疗方法。鉴于新药开发目前的特点是成本和开发时间的大幅增加，药物重新定位、为现有批准的药物寻找新用途或药物重新用途、当新的分子发现使旧药物再次具有吸引力时重新使用旧药物，在临床药理学中越来越重要，因为它允许更快、更便宜地将潜在有用的药物从试验台输送到床边。这一点在胶质母细胞瘤中相当明显，一些旧药物现在被考虑用于临床，通常与一线治疗干预相关联。有趣的是，这些药物中的大多数几十年来一直被广泛用于非肿瘤病理，而没有相关的副作用。现在，通过最新技术对它们的分子作用机制(S)的改进正在为它们用于胶质母细胞瘤和其他癌症类型的治疗铺平道路。新的抗肿瘤药物价格螺旋式上升，需要很长时间才能上市，这要求采取一种截然不同的方法，让癌症患者能够负担得起挽救生命的疗法。在这种情况下，重新定位可以代表一种相对便宜、安全和快速的胶质母细胞瘤治疗方法。为此，必须准确考虑利弊。
Glioblastoma Multiforme is the deadliest type of brain tumor and is characterized by very poor prognosis with a limited overall survival. Current optimal therapeutic approach has essentially remained unchanged for more than a decade, consisting in maximal surgical resection followed by radiotherapy plus temozolomide. Such a dismal patient outcome represents a compelling need for innovative and effective therapeutic approaches. Given the development of new drugs is a process presently characterized by an immense increase in costs and development time, drug repositioning, finding new uses for existing approved drugs or drug repurposing, re-use of old drugs when novel molecular findings make them attractive again, are gaining significance in clinical pharmacology, since it allows faster and less expensive delivery of potentially useful drugs from the bench to the bedside. This is quite evident in glioblastoma, where a number of old drugs is now considered for clinical use, often in association with the first-line therapeutic intervention. Interestingly, most of these medications are, or have been, widely employed for decades in non-neoplastic pathologies without relevant side effects. Now, the refinement of their molecular mechanism(s) of action through up-to-date technologies is paving the way for their use in the therapeutic approach of glioblastoma as well as other cancer types. The spiraling costs of new antineoplastic drugs and the long time required for them to reach the market demands a profoundly different approach to keep lifesaving therapies affordable for cancer patients. In this context, repurposing can represent a relatively inexpensive, safe and fast approach to glioblastoma treatment. To this end, pros and cons must be accurately considered.
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影响因子：
5.2
作者：
Choi, Dong Soon;Blanco, Elvin;Kim, Yoo-Shin;Rodriguez, Angel A.;Zhao, Hong;Huang, Tim Hui-Ming;Chen, Chun-Liang;Jin, Guangxu;Landis, Melissa D.;Burey, Lacey A.;Qian, Wei;Granados, Sergio M.;Dave, Bhuvanesh;Wong, Helen H.;Ferrari, Mauro;Wong, Stephen T. C.;Chang, Jenny C.
通讯作者：
Chang, Jenny C.
影响因子：
3.6
作者：
COULSTON, F;DOUGHERTY, WJ;SILVESTRINI, B
通讯作者：
SILVESTRINI, B
影响因子：
50.3
作者：
Dolma S;Selvadurai HJ;Lan X;Lee L;Kushida M;Voisin V;Whetstone H;So M;Aviv T;Park N;Zhu X;Xu C;Head R;Rowland KJ;Bernstein M;Clarke ID;Bader G;Harrington L;Brumell JH;Tyers M;Dirks PB
通讯作者：
Dirks PB
DOI：
10.1073/pnas.83.21.8333
发表时间：
1986-11-01
影响因子：
11.1
作者：
FURMAN, PA;FYFE, JA;BARRY, DW
通讯作者：
BARRY, DW
影响因子：
20.3
作者：
Bride, Karen L.;Vincent, Tiffaney;Teachey, David T.
通讯作者：
Teachey, David T.