Regenerating β cells of the pancreas - potential developments in diabetes treatment.
Regenerating β cells of the pancreas - potential developments in diabetes treatment.
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DOI：
10.1080/14712598.2018.1402885
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发表时间：
2018-03
影响因子：
4.6
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Dong S;Wu H
糖尿病的病因主要是由于β细胞缺乏而导致胰岛素缺乏（1型），或胰岛素抵抗最终导致β细胞功能障碍（2型）。因此，糖尿病的最终治愈需要能够替代丢失的胰岛素分泌β细胞。 β细胞再生策略正在广泛研究中。在此，作者首先总结了胚胎β细胞发育和成人β细胞自发再生的机制，为开发β细胞再生策略奠定了基础。然后回顾了每种β细胞再生策略的基本原理和进展。目前的β细胞再生策略可分为两大类：利用多能干细胞的体外β细胞再生和体内将非β细胞重编程为β细胞。每个都有自己的优点和缺点。再生β细胞已显示出其治疗胰岛素缺乏型糖尿病的潜力。已经取得了很大进展，β细胞再生疗法越来越接近临床现实。然而，在所建议的任何策略能够从实验室完全转化为临床之前，还需要克服更多障碍。
The etiology of diabetes is mainly attributed to insulin deficiency due to the lack of β cells (type 1), or to insulin resistance that eventually results in β cell dysfunction (type 2). Therefore, an ultimate cure for diabetes requires the ability to replace the lost insulin-secreting β cells. Strategies for regenerating β cells are under extensive investigation. Herein, the authors first summarize the mechanisms underlying embryonic β cell development and spontaneous adult β cell regeneration, which forms the basis for developing β cell regeneration strategies. Then the rationale and progress of each β cell regeneration strategy is reviewed. Current β cell regeneration strategies can be classified into two main categories: in vitro β cell regeneration using pluripotent stem cells and in vivo reprogramming of non-β cells into β cells. Each has its own advantages and disadvantages. Regenerating β cells has shown its potential as a cure for the treatment of insulin-deficient diabetes. Much progress has been made, and β cell regeneration therapy is getting closer to a clinical reality. Nevertheless, more hurdles need to be overcome before any of the strategies suggested can be fully translated from bench to bedside.
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影响因子：
9.8
作者：
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DOI：
10.1073/pnas.97.14.7999
发表时间：
2000-07-05
影响因子：
11.1
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