The transient receptor potential family of ion channels.
The transient receptor potential family of ion channels.
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DOI：
10.1186/gb-2011-12-3-218
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发表时间：
2011
期刊：
影响因子：
12.3
通讯作者：
Owsianik G
中科院分区：
文献类型：
--
作者：
Nilius B;Owsianik G
瞬时受体电位 (TRP) 多基因超家族编码充当离子通道的整合膜蛋白。该家族的成员在酵母、无脊椎动物和脊椎动物中是保守的。 TRP家族又分为7个亚家族：TRPC（规范）、TRPV（香草素）、TRPM（褪黑素）、TRPP（多囊蛋白）、TRPML（粘磷脂）、TRPA（锚蛋白）和TRPN（NOMPC样）；后者仅存在于无脊椎动物和鱼类中。 TRP离子通道广泛表达于许多不同的组织和细胞类型中，参与不同的生理过程，例如不同刺激的感觉或离子稳态。大多数 TRP 是非选择性阳离子通道，只有少数具有高 Ca2+ 选择性，有些甚至对高水合 Mg2+ 离子具有渗透性。该通道家族表现出多种门控机制，激活模式范围从配体结合、电压和温度变化到亲核残基的共价修饰。激活的TRP通道引起细胞膜去极化，进而激活电压依赖性离子通道，导致细胞内Ca2+浓度发生变化；它们充当多种阳离子（例如 Ca2+ 和 Mg2+）跨细胞运输的看门人，并且是细胞内细胞器（例如内体和溶酶体）功能所必需的。由于它们作为细胞内 Ca2+ 释放通道的功能，它们在细胞器中具有重要的调节作用。一些 TRP 基因的突变与多种病理状态有关，包括神经退行性疾病、骨骼发育不良、肾脏疾病和疼痛，正在进行的研究可能有助于找到治疗相关疾病的新疗法。
The transient receptor potential (TRP) multigene superfamily encodes integral membrane proteins that function as ion channels. Members of this family are conserved in yeast, invertebrates and vertebrates. The TRP family is subdivided into seven subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), TRPA (ankyrin) and TRPN (NOMPC-like); the latter is found only in invertebrates and fish. TRP ion channels are widely expressed in many different tissues and cell types, where they are involved in diverse physiological processes, such as sensation of different stimuli or ion homeostasis. Most TRPs are non-selective cation channels, only few are highly Ca2+ selective, some are even permeable for highly hydrated Mg2+ ions. This channel family shows a variety of gating mechanisms, with modes of activation ranging from ligand binding, voltage and changes in temperature to covalent modifications of nucleophilic residues. Activated TRP channels cause depolarization of the cellular membrane, which in turn activates voltage-dependent ion channels, resulting in a change of intracellular Ca2+ concentration; they serve as gatekeeper for transcellular transport of several cations (such as Ca2+ and Mg2+), and are required for the function of intracellular organelles (such as endosomes and lysosomes). Because of their function as intracellular Ca2+ release channels, they have an important regulatory role in cellular organelles. Mutations in several TRP genes have been implicated in diverse pathological states, including neurodegenerative disorders, skeletal dysplasia, kidney disorders and pain, and ongoing research may help find new therapies for treatments of related diseases.
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DOI：
10.1085/jgp.200810137
发表时间：
2009-03
期刊：
The Journal of general physiology
影响因子：
--
作者：
Gaudet R
通讯作者：
Gaudet R
影响因子：
16.6
作者：
Dong, Xian-ping;Shen, Dongbiao;Wang, Xiang;Dawson, Taylor;Li, Xinran;Zhang, Qi;Cheng, Xiping;Zhang, Yanling;Weisman, Lois S.;Delling, Markus;Xu, Haoxing
通讯作者：
Xu, Haoxing
影响因子：
10.7
作者：
Cai, Xinjiang
通讯作者：
Cai, Xinjiang
影响因子：
3.3
作者：
Bellone, Rebecca R.;Brooks, Samantha A.;Grahn, Bruce
通讯作者：
Grahn, Bruce
DOI：
10.1073/pnas.1005333107
发表时间：
2010-11-02
影响因子：
11.1
作者：
Everaerts, Wouter;Zhen, Xiaoguang;Voets, Thomas
通讯作者：
Voets, Thomas