Using the common cold virus as a naturally occurring vaccine to prevent COVID-19: Lessons from Edward Jenner.

Using the common cold virus as a naturally occurring vaccine to prevent COVID-19: Lessons from Edward Jenner.
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使用普通感冒病毒作为自然产生的疫苗预防新冠肺炎:爱德华·詹纳的教训。

DOI:
10.18632/aging.104166
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发表时间:
2020-10-13
期刊:
Aging
影响因子:
--
通讯作者:
Lisanti MP
Lisanti MP
中科院分区:
其他
文献类型:
--
作者:
Sotgia F;Lisanti MP

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最近在《自然》、《科学》和《细胞》杂志上发表的三篇论文均提供了明确的证据,表明与普通感冒有关的人类冠状病毒(229E、NL63、OC43 和 HKU1)与 COVID-19 的病原体 SARS-CoV-2 之间存在交叉反应性 T 细胞免疫。我们能否利用这些信息来设计和构建基于致病性较低的普通感冒冠状病毒的新疫苗来预防 COVID-19?如果我们回顾一下医学和疫苗开发的历史,从爱德华·詹纳的角度来看,答案可能是肯定的。
Three recent papers published in Nature, Science and Cell, all present clear evidence that there is cross-reactive T-cell immunity between human coronaviruses (229E, NL63, OC43, and HKU1), linked with the common cold, and SARS-CoV-2, the causative agent of COVID-19. Can we use this information to design and build a new vaccine based on the less pathogenic, common cold coronaviruses, for the prevention of COVID-19? If we look at the history of medicine and vaccine development, from the point of view of Edward Jenner, the answer just might be yes.
DOI: 10.1038/s41586-020-2598-9
发表时间: 2020-07-29
期刊: NATURE
影响因子: 64.8
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