Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans.
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans.
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DOI：
10.1126/science.abd3871
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发表时间：
2020-10-02
期刊：
影响因子：
--
通讯作者：
Weiskopf D
中科院分区：
文献类型：
--
作者：
Mateus J;Grifoni A;Tarke A;Sidney J;Ramirez SI;Dan JM;Burger ZC;Rawlings SA;Smith DM;Phillips E;Mallal S;Lammers M;Rubiro P;Quiambao L;Sutherland A;Yu ED;da Silva Antunes R;Greenbaum J;Frazier A;Markmann AJ;Premkumar L;de Silva A;Peters B;Crotty S;Sette A;Weiskopf D
大多数冠状病毒病2019年患者(新冠肺炎)对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)病毒产生强大的T细胞反应。一些研究已经报道，一些没有接触过SARS-CoV-2的人对SARS-CoV-2序列具有预先存在的反应性。这种预先存在的反应的免疫学机制尚不清楚，但可能与先前接触广泛传播的普通感冒冠状病毒有关。Mateus等人。研究发现，针对SARS-CoV-2的预先存在的反应性来自记忆T细胞，并且交叉反应的T细胞可以特异性识别SARS-CoV-2表位以及普通感冒冠状病毒的同源表位。这些发现强调了确定先前存在的免疫记忆对新冠肺炎疾病严重程度的影响的重要性。科学，本期第89页先前存在的对SARS-CoV-2的免疫力可以源自导致普通感冒的冠状病毒。关于人类对严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)病毒的免疫反应，存在许多未知因素。据报道，在未接触SARS-CoV-2病毒的个体中，有反应性的CD4+T细胞，这表明在20%到50%的人中先前存在交叉反应性T细胞记忆。然而，这些T细胞的来源一直是推测的。利用2019年SARS-CoV-2病毒被发现之前提取的人类血液样本，我们在SARS-CoV-2基因组中映射了142个T细胞表位，以便于精确询问SARS-CoV-2特异性的CD4+T细胞谱系。我们展示了一系列预先存在的记忆CD4+T细胞，它们与SARS-CoV-2和常见的感冒冠状病毒(HCoV)-OC43、HCoV-229E、HCoV-NL63和HCoV-HKU1具有类似的亲和力。因此，导致普通感冒的冠状病毒对T细胞的记忆可能至少是冠状病毒2019年(新冠肺炎)疾病中观察到的广泛异质性的一部分。
Robust T cell responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus occur in most individuals with coronavirus disease 2019 (COVID-19). Several studies have reported that some people who have not been exposed to SARS-CoV-2 have preexisting reactivity to SARS-CoV-2 sequences. The immunological mechanisms underlying this preexisting reactivity are not clear, but previous exposure to widely circulating common cold coronaviruses might be involved. Mateus et al. found that the preexisting reactivity against SARS-CoV-2 comes from memory T cells and that cross-reactive T cells can specifically recognize a SARS-CoV-2 epitope as well as the homologous epitope from a common cold coronavirus. These findings underline the importance of determining the impacts of preexisting immune memory in COVID-19 disease severity. Science, this issue p. 89 Preexisting immunity against SARS-CoV-2 can be derived from coronaviruses that cause the common cold. Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have been reported in unexposed individuals, suggesting preexisting cross-reactive T cell memory in 20 to 50% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2–specific CD4+ T cell repertoire. We demonstrate a range of preexisting memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses human coronavirus (HCoV)-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in coronavirus disease 2019 (COVID-19) disease.
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DOI：
10.1111/cea.12692
发表时间：
2016-05
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Hinz D;Seumois G;Gholami AM;Greenbaum JA;Lane J;White B;Broide DH;Schulten V;Sidney J;Bakhru P;Oseroff C;Wambre E;James EA;Kwok WW;Peters B;Vijayanand P;Sette A
通讯作者：
Sette A
影响因子：
6.7
作者：
Lindestam Arlehamn CS;McKinney DM;Carpenter C;Paul S;Rozot V;Makgotlho E;Gregg Y;van Rooyen M;Ernst JD;Hatherill M;Hanekom WA;Peters B;Scriba TJ;Sette A
通讯作者：
Sette A
影响因子：
5.4
作者：
Grifoni, Alba;Voic, Hannah;Sette, Alessandro
通讯作者：
Sette, Alessandro
影响因子：
56.9
作者：
Kissler, Stephen M.;Tedijanto, Christine;Lipsitch, Marc
通讯作者：
Lipsitch, Marc
影响因子：
6.1
作者：
Hinz, D.;Oseroff, C.;Sette, A.
通讯作者：
Sette, A.