Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease.
Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease.
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DOI：
10.1186/1475-2840-13-44
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发表时间：
2014-02-14
影响因子：
9.3
通讯作者：
Katare R
中科院分区：
文献类型：
--
作者：
Rawal S;Manning P;Katare R
糖尿病性心脏病（Diabetic Heart Disease，DHD）是糖尿病患者发病和死亡的主要原因，约80%的糖尿病患者死于心血管并发症。重要的是，糖尿病患者的心脏病在更早的阶段发展，尽管直到疾病的后期仍保持无症状，从而限制了其早期检测和积极的治疗管理。因此，更好地了解参与DHD病理生理学的调节剂对于早期诊断和开发糖尿病相关心血管并发症的新治疗意义是必要的。microRNA（miRs）通过调控心脏基因表达，在多种心血管事件中发挥重要作用。除了它们可信地参与控制细胞过程之外，它们还在疾病状态下释放到循环中，在那里它们作为心血管疾病的潜在诊断生物标志物。然而，它们在DHD中作为调节剂以及诊断生物标志物的潜在作用在很大程度上未被探索。在这篇综述中，我们描述了所选的心血管miR与心血管疾病相关的假定机制，并讨论了它们可能参与DHD的病理生理学和早期诊断。
Diabetic heart disease (DHD) is the leading cause of morbidity and mortality among the people with diabetes, with approximately 80% of the deaths in diabetics are due to cardiovascular complications. Importantly, heart disease in the diabetics develop at a much earlier stage, although remaining asymptomatic till the later stage of the disease, thereby restricting its early detection and active therapeutic management. Thus, a better understanding of the modulators involved in the pathophysiology of DHD is necessary for the early diagnosis and development of novel therapeutic implications for diabetes-associated cardiovascular complications. microRNAs (miRs) have recently been evolved as key players in the various cardiovascular events through the regulation of cardiac gene expression. Besides their credible involvement in controlling the cellular processes, they are also released in to the circulation in disease states where they serve as potential diagnostic biomarkers for cardiovascular disease. However, their potential role in DHD as modulators as well as diagnostic biomarkers is largely unexplored. In this review, we describe the putative mechanisms of the selected cardiovascular miRs in relation to cardiovascular diseases and discuss their possible involvement in the pathophysiology and early diagnosis of DHD.
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