Multimodal Interactions between Proprioceptive and Cutaneous Signals in Primary Somatosensory Cortex.
Multimodal Interactions between Proprioceptive and Cutaneous Signals in Primary Somatosensory Cortex.
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DOI：
10.1016/j.neuron.2015.03.020
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发表时间：
2015-04-22
期刊：
影响因子：
16.2
通讯作者：
Hsiao, Steven S.
中科院分区：
文献类型：
--
作者：
Kim, Sung Soo;Gomez-Ramirez, Manuel;Thakur, Pramodsingh H.;Hsiao, Steven S.
The classical view of somatosensory processing holds that proprioceptive and cutaneous inputs are conveyed to cortex through segregated channels, initially synapsing in modality-specific areas 3a (proprioception) and 3b (cutaneous) of primary somatosensory cortex (SI). These areas relay their signals to areas 1 and 2 where multimodal convergence first emerges. However, proprioceptive and cutaneous maps have traditionally been characterized using unreliable stimulation tools. Here, we employed a mechanical stimulator that reliably positioned animals' hands in different postures and presented tactile stimuli with superb precision. Single-unit recordings in SI revealed that most neurons responded to cutaneous and proprioceptive stimuli, including cells in areas 3a and 3b. Multimodal responses were characterized by linear and nonlinear effects that emerged during early (∼20ms) and latter (>100ms) stages of stimulus processing, respectively. These data are incompatible with the modality specificity model in SI, and provide evidence for distinct mechanisms of multimodal processing in the somatosensory system.
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影响因子：
2.5
作者：
COHEN, DAD;PRUDHOMME, MJL;KALASKA, JF
通讯作者：
KALASKA, JF
影响因子：
3
作者：
Lane, John W.;Fitzgerald, Paul J.;Yau, Jeffrey M.;Pembeci, Izzet;Hsiao, Steven S.
通讯作者：
Hsiao, Steven S.
影响因子：
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Fitzgerald, Paul J.;Lane, John W.;Hsiao, Steven S.
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影响因子：
5.3
作者：
Bensmaia, Sliman J.;Denchev, Peter V.;Hsiao, Steven S.
通讯作者：
Hsiao, Steven S.