International Web-based consultation on priorities for translational breast cancer research.
International Web-based consultation on priorities for translational breast cancer research.
复制标题
DOI：
10.1186/bcr1798
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Viale G
中科院分区：
文献类型：
--
作者：
Dowsett M;Goldhirsch A;Hayes DF;Senn HJ;Wood W;Viale G
大量的转化性乳腺癌研究课题已经完成或正在进行中，但它们对临床管理的当前和/或未来重要性差异很大。因此，我们对乳腺癌专业人员进行了一次国际网络咨询，以确定最被广泛认为是最优先的主题。通过两个大型电子邮件数据库联系潜在的参与者，并要求他们在一个网站上登记他们认为最优先的问题。指导委员会将490个问题减少到70个独特的问题，并要求注册者选择他们认为最重要的6个问题。共有来自48个国家的420名选民（2520张选票）投票，其中48%的选民来自北美。一半的选民认为自己是临床医生，其余的是学者、研究科学家或病理学家。最优先考虑的是识别分子特征，以选择可以免于化疗的患者，这比第二个主题获得了约50%的选票，并且在北美，欧洲和世界其他地区的选民中一直名列前茅。研究科学家认为确定干细胞在乳腺癌的发展、进展和治疗敏感性中的作用是最重要的问题，但这被认为是临床医生的第六大优先事项，也是第四大优先事项。这项工作可能使研究资源更集中于被认为是最优先事项的问题。
Large numbers of translational breast cancer research topics have been completed or are underway, but they differ widely in their immediate and/or future importance to clinical management. We therefore conducted an international Web-based consultation of breast cancer professionals to identify the topics most widely considered to be of highest priority. Potential participants were contacted via two large e-mail databases and asked to register, at a Web site, the issues that they felt to be of highest priority. Four hundred nine questions were reduced by a steering committee to 70 unique issues, and registrants were asked to select the 6 questions they considered to be the most important. Votes were recorded from 420 voters (2,520 votes) from 48 countries, with 48% of voters coming from North America. Half of the voters identified themselves as clinicians, with the remainder being academics, research scientists, or pathologists. The highest priority was to identify molecular signatures to select patients who could be spared chemotherapy, which gained about 50% more votes than the second topic and was consistently voted top by voters in North America, Europe, and the rest of the world. Research scientists voted the determination of the role of stem cells in breast cancer development, progression, and treatment sensitivity as the most important issue, but this was considered the sixth priority for clinicians and fourth overall. This exercise may bring a greater focus of research resources onto issues voted as top priorities.
登录
查看更多内容
影响因子：
158.5
作者：
van de Vijver, MJ;He, YD;Bernards, R
通讯作者：
Bernards, R
影响因子：
3.1
作者：
Sparano, Joseph A.
通讯作者：
Sparano, Joseph A.
影响因子：
3.4
作者：
Banerjee, S.;Reis-Filho, J. S.;Smith, I. E.
通讯作者：
Smith, I. E.
影响因子：
50.5
作者：
Goldhirsch, A;Colleoni, M;Gelber, RD
通讯作者：
Gelber, RD
DOI：
10.1073/pnas.191367098
发表时间：
2001-09-11
影响因子：
11.1
作者：
Sorlie, T;Perou, CM;Borresen-Dale, AL
通讯作者：
Borresen-Dale, AL