SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism.
SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism.
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DOI：
10.1007/s12035-020-02245-1
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发表时间：
2021-06
影响因子：
5.1
通讯作者：
Lakshmana MK
中科院分区：
文献类型：
--
作者：
Karuppan MKM;Devadoss D;Nair M;Chand HS;Lakshmana MK
最近爆发的SARS-CoV-2感染导致2019年冠状病毒引起的疾病（COVID-19）是我们这个时代规模和程度都前所未有的全球健康危机。虽然呼吸道是SARS-CoV-2的主要靶点，但越来越多的证据表明，该病毒也可能侵入中枢神经系统（CNS）和外周神经系统（PNS），导致许多神经系统问题，包括一些严重的并发症，如癫痫发作、脑炎和意识丧失。在这里，我们对目前已知的SARS-CoV-2的作用进行了全面的回顾，并确定了世界各地COVID-19病例报告中报告的所有神经系统问题。该病毒可能通过嗅觉神经元的跨突触途径或通过脑微血管中受损的内皮细胞使用神经纤毛蛋白-1（NRP-1）增强的ACE 2受体进入CNS。所有症状中最严重的似乎是一些COVID-19患者的自主呼吸丧失。这可能表明脑干中的心肺调节中心功能障碍。因此，这些开创性的研究为更深入的基础和临床研究奠定了坚实的基础，这些研究需要确认SARS-CoV-2感染在关键脑调节中心神经变性中的作用。
The recent outbreak of SARS-CoV-2 infections that causes coronavirus-induced disease of 2019 (COVID-19) is the defining and unprecedented global health crisis of our time in both the scale and magnitude. Although the respiratory tract is the primary target of SARS-CoV-2, accumulating evidence suggests that the virus may also invade both the central nervous system (CNS) and the peripheral nervous system (PNS) leading to numerous neurological issues including some serious complications such as seizures, encephalitis, and loss of consciousness. Here, we present a comprehensive review of the currently known role of SARS-CoV-2 and identify all the neurological problems reported among the COVID-19 case reports throughout the world. The virus might gain entry into the CNS either through the trans-synaptic route via the olfactory neurons or through the damaged endothelium in the brain microvasculature using the ACE2 receptor potentiated by neuropilin-1 (NRP-1). The most critical of all symptoms appear to be the spontaneous loss of breathing in some COVID-19 patients. This might be indicative of a dysfunction within the cardiopulmonary regulatory centers in the brainstem. These pioneering studies, thus, lay a strong foundation for more in-depth basic and clinical research required to confirm the role of SARS-CoV-2 infection in neurodegeneration of critical brain regulatory centers.
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影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
影响因子：
2.7
作者：
Chasey D;Alexander DJ
通讯作者：
Alexander DJ
影响因子：
19.6
作者：
Cheng, Yichun;Luo, Ran;Xu, Gang
通讯作者：
Xu, Gang
DOI：
10.1016/0034-5687(95)00050-x
发表时间：
1996-01-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Banzett, RB;Lansing, RW;Shea, SA
通讯作者：
Shea, SA
影响因子：
29
作者：
Abdel-Mannan, Omar;Eyre, Michael;Hacohen, Yael
通讯作者：
Hacohen, Yael