Down-regulation of a signaling mediator in association with lowered plasma arachidonic acid levels in individuals with autism spectrum disorders
Down-regulation of a signaling mediator in association with lowered plasma arachidonic acid levels in individuals with autism spectrum disorders
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信号传导介质的下调与自闭症谱系障碍患者血浆花生四烯酸水平降低相关
DOI：
10.1016/j.neulet.2015.11.006
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发表时间：
2016
影响因子：
2.5
通讯作者：
H. Yamada
中科院分区：
文献类型：
--
作者：
K. Yui;G. Imataka;Y. Kawasaki;H. Yamada
以往的研究表明，改变组成的多不饱和脂肪酸（PUFA）可能有助于自闭症谱系障碍（ASD）的病理生理。我们检测了血浆脂肪酸水平（以μg/ml表示）与AA相关信号介质生物标志物（如血浆铜蓝蛋白、转铁蛋白和超氧化物歧化酶）血浆水平之间的关系，并评估了30名ASD患者的行为症状（平均年龄，13.6 ± 4.3岁）与20名年龄和性别匹配的正常对照（平均年龄，13.2 ± 5.4岁）进行比较，使用异常行为检查表（ABC）。与20名正常人相比，30名ASD患者血浆EPA水平和EPA/AA比值显著升高，而AA及其代谢产物5，8，11，14-二十碳四烯酸、肾上腺酸和血浆铜蓝蛋白（Cp）水平显著降低。ASD组ABC评分较对照组明显增高。因此，本研究的结果表明，AA和代谢产物的血浆水平降低与高血浆EPA/AA比值可能下调AA相关的信号介质，如Cp。随后，血浆Cp水平降低可能会降低脑损伤的保护能力，导致ASD患者行为症状的病理生理学基础。这些结果表明，降低血浆AA水平可能下调Cp。
Previous studies have indicated that the altered composition of polyunsaturated fatty acids (PUFAs) might contribute to the pathophysiology of autism spectrum disorder (ASD). We examined the relationship between the plasma fatty acid levels, expressed as μg/ml, and the plasma levels of biomarkers of AA-related signaling mediators, such as ceruloplasmin, transferrin and superoxide dismutase, and assessed the behavioral symptoms of 30 individuals with ASD (mean age, 13.6 ± 4.3 years old) compared with 20 age- and gender-matched normal controls (mean age, 13.2 ± 5.4 years old) using Aberrant Behavior Checklists (ABC). The plasma levels of EPA and the plasma ratios of EPA/AA were significantly higher, while the plasma levels of AA and metabolites, such as 5,8,11,14-eicosatetraenoic acid, adrenic acid, and ceruloplasmin (Cp), were significantly lower in the 30 individuals with ASD compared with the 20 normal controls. The ABC scores were significantly increased in the ASD group compared with those of the control group. Thus, the results of the present study revealed that reduced plasma levels of AA and metabolites in association with high plasma EPA/AA ratios might down-regulate AA-related signaling mediators, such as Cp. Subsequently, reduced plasma Cp levels might reduce the protective capacity for brain damage, resulting in the pathophysiology underlying the behavioral symptoms in individuals with ASD. These findings suggest that reduced plasma AA levels may downregulate Cp.
DOI：
10.1016/j.plefa.2014.02.003
发表时间：
2014-05
期刊：
Prostaglandins, leukotrienes, and essential fatty acids
影响因子：
--
作者：
Taha AY;Cheon Y;Faurot KF;Macintosh B;Majchrzak-Hong SF;Mann JD;Hibbeln JR;Ringel A;Ramsden CE
通讯作者：
Ramsden CE
DOI：
10.1016/j.bbalip.2014.04.006
发表时间：
2014-08
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Holowka D;Korzeniowski MK;Bryant KL;Baird B
通讯作者：
Baird B
影响因子：
4.8
作者：
Werling DM;Geschwind DH
通讯作者：
Geschwind DH