Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools.
Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools.
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DOI：
10.1016/j.plefa.2014.02.003
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Ramsden CE
中科院分区：
文献类型：
--
作者：
Taha AY;Cheon Y;Faurot KF;Macintosh B;Majchrzak-Hong SF;Mann JD;Hibbeln JR;Ringel A;Ramsden CE
饲粮降低亚油酸（LA, 18:2n-6）可降低n-6多不饱和脂肪酸（PUFA）血浆浓度，提高n-3 PUFA(二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）浓度。评估12周饮食中n-6 PUFA的降低，加上或不增加饮食中n-3 PUFA，对慢性头痛患者未酯化和酯化血浆n-6和n-3 PUFA浓度的改变程度。随机试验的二次分析。慢性头痛患者被随机分配12周：(1)平均n-3，低n-6 （L6）饮食；或(2)高n-3、低n-6 LA （H3-L6）饲料。在基线（0周）和饮食12周后对酯化和未酯化血浆脂肪酸进行量化。与基线相比，L6日粮降低了酯化血浆LA，增加了酯化n-3 PUFA浓度（nmol/ml），但没有显著改变血浆花生四烯酸（AA, 20:4n-6）浓度。此外，未酯化脂肪酸中未酯化的EPA浓度显著增加。H3-L6日粮降低了酯化LA和AA浓度，并产生了更显著的酯化和未酯化n-3 PUFA浓度升高。饲粮中降低n-6 PUFA 12周后，血浆中n-3 PUFA浓度显著降低LA，增加血浆中n-3 PUFA浓度，但不改变血浆AA浓度。饮食中n-3 PUFA同时增加12周，进一步增加n-3 PUFA血浆浓度，但也降低AA。
Dietary linoleic acid (LA, 18:2n-6) lowering in rats reduces n-6 polyunsaturated fatty acid (PUFA) plasma concentrations and increases n-3 PUFA (eicosapentaenoic (EPA) and docosahexaenoic acid (DHA)) concentrations. To evaluate the extent to which 12 weeks of dietary n-6 PUFA lowering, with or without increased dietary n-3 PUFAs, change unesterified and esterified plasma n-6 and n-3 PUFA concentrations in subjects with chronic headache. Secondary analysis of a randomized trial. Subjects with chronic headache were randomized for 12 weeks to: (1) average n-3, low n-6 (L6) diet; or (2) high n-3, low n-6 LA (H3-L6) diet. Esterified and unesterified plasma fatty acids were quantified at baseline (0 weeks) and after 12 weeks on a diet. Compared to baseline, the L6 diet reduced esterified plasma LA and increased esterified n-3 PUFA concentrations (nmol/ml), but did not significantly change plasma arachidonic acid (AA, 20:4n-6) concentration. In addition, unesterified EPA concentration was increased significantly among unesterified fatty acids. The H3-L6 diet decreased esterified LA and AA concentrations, and produced more marked increases in esterified and unesterified n-3 PUFA concentrations. Dietary n-6 PUFA lowering for 12 weeks significantly reduces LA and increases n-3 PUFA concentrations in plasma, without altering plasma AA concentration. A concurrent increase in dietary n-3 PUFA for 12 weeks further increases n-3 PUFA plasma concentrations, but also reduces AA.
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DOI：
10.1016/j.bbalip.2010.10.005
发表时间：
2011-02
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Kim HW;Rao JS;Rapoport SI;Igarashi M
通讯作者：
Igarashi M
影响因子：
7.1
作者：
Friesen, Russell W.;Innis, Sheila M.
通讯作者：
Innis, Sheila M.
影响因子：
1.9
作者：
Bazinet, RP;Douglas, H;Cunnane, SC
通讯作者：
Cunnane, SC
影响因子：
5.1
作者：
CLARK, KJ;MAKRIDES, M;GIBSON, RA
通讯作者：
GIBSON, RA
影响因子：
4.1
作者：
KINGSBURY, K;PAUL, S;CROSSLEY, A
通讯作者：
CROSSLEY, A