Elevation of fibronectin levels in lung secretions of infants with respiratory distress syndrome and development of bronchopulmonary dysplasia.
Elevation of fibronectin levels in lung secretions of infants with respiratory distress syndrome and development of bronchopulmonary dysplasia.
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患有呼吸窘迫综合征和支气管肺发育不良的婴儿肺分泌物中纤连蛋白水平升高。
DOI：
10.1016/s0022-3476(05)82492-8
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Bruce,MC
中科院分区：
文献类型：
--
作者：
Watts,CL;Fanaroff,AA;Bruce,MC
为了确定肺分泌物中纤维连接蛋白的水平是否与肺损伤的严重程度或与支气管肺发育不良的发展相关，或两者兼有，我们收集了32例患有严重呼吸窘迫综合征的早产儿的气管吸入样本。测定14例无肺后遗症康复的婴儿出生后1 ~ 2周和18例支气管肺发育不良的婴儿出生后1 ~ 4周的总纤维连接蛋白、细胞纤维连接蛋白、血浆纤维连接蛋白、白蛋白和IgA （SC）分泌成分水平。之所以选择分泌成分作为参考蛋白，是因为其在肺分泌物中的浓度受毛细血管渗漏的影响最小，且不随胎龄或出生后年龄的变化而变化。在支气管肺发育不良的婴儿出生后的前2周，气管吸入物中白蛋白/SC和血浆纤维连接蛋白/SC的比值显著升高（p<0.05），表明这些婴儿的毛细血管渗透性更大。支气管肺发育不良患儿吸出液中纤维连接蛋白/SC的比值在前2周分别为9.0±1.7和7.4±2.0 μg/μ SC，而非支气管肺发育不良患儿吸出液中纤维连接蛋白/SC的比值分别为1.6±0.4和1.1±0.8 μg/μ SC (p<0.01)，提示支气管肺发育不良患儿肺中纤维连接蛋白合成增加。气管吸入样本中血浆和细胞纤维连接蛋白水平升高可能提供严重呼吸窘迫综合征婴儿肺损伤严重程度的早期指标。
To determine whether the level of fibronectin in lung secretions correlates with the severity of lung injury or with the development of bronchopulmonary dysplasia, or both, serial tracheal aspirate samples were collected from 32 preterm infants with severe respiratory distress syndrome. Levels of total fibronectin, cellular fibronectin, plasma fibronectin, albumin, and secretory component of IgA (SC) were determined for the first 1 to 2 weeks of life in the 14 infants who recovered without pulmonary sequelae, and for weeks 1 to 4 in the 18 infants in whom bronchopulmonary dysplasia developed. Secretory component was chosen as the reference protein because its concentration in lung secretions is minimally influenced by capillary leak and does not vary with gestational or postnatal age. Albumin/SC and plasma fibronectin/SC ratios in tracheal aspirates were significantly higher (p<0.05) during the first 2 weeks of life in infants in whom bronchopulmonary dysplasia developed, suggesting greater capillary permeability in these infants. Cellular fibronectin/SC ratios in aspirates from infants with bronchopulmonary dysplasia were also significantly higher in the first 2 weeks, 9.0±1.7 and 7.4±2.0 μg/μg SC in weeks 1 and 2, respectively, in comparison with values from infants without bronchopulmonary dysplasia, 1.6±0.4 and 1.1±0.8 μg/μg SC (p<0.01), suggesting increased synthesis of fibronectin in the lungs of infants with subsequent bronchopulmonary dysplasia. Elevated levels of both plasma and cellular fibronectin in tracheal aspirate samples may provide an early index of the severity of lung injury in infants with severe respiratory distress syndrome.
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成纤维细胞层中因子 XIIIa 介导的纤连蛋白交联。
DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Barry,EL;Mosher,DF
通讯作者：
Mosher,DF
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DOI：
--
发表时间：
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期刊：
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DOI：
--
发表时间：
1980
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
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作者：
Gauss;Kleinman Hk;Martin Gr;E. Schiffmann
通讯作者：
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DOI：
10.1164/arrd.1984.130.5.817
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Ogden,BE;Murphy,SA;Saunders,GC;Pathak,D;Johnson,JD
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影响因子：
14.9
作者：
A. Kornblihtt;K. Vibe;F. Baralle
通讯作者：
F. Baralle