Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report.
Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report.
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DOI：
10.1186/cc3034
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发表时间：
2005-04
期刊：
影响因子：
15.1
通讯作者：
Bellomo, R
中科院分区：
文献类型：
--
作者：
Naka, T;Jones, D;Baldwin, I;Fealy, N;Bates, S;Goehl, H;Morgera, S;Neumayer, HH;Bellomo, R
研究一种新型的大孔径超高通量膜对血清中肌红蛋白的清除能力。一所大学教学医院的重症监护室。1例5-羟色胺综合征并发重度横纹肌溶解症和少尿性急性肾功能衰竭的患者。最初，使用标准聚砜1.4 m2膜以2 l/h超滤（UF）进行连续静脉-静脉血液滤过（临界点，20 kDa），然后使用SHF膜进行连续静脉-静脉血液滤过（临界点，100 kDa），然后以3 l/h UF，然后以4 l/h UF，试图清除肌红蛋白。在2 l/h交换时，使用SHF膜的超滤液中肌红蛋白浓度至少是使用常规膜的5倍（> 100，000 μg/l vs 23，003 μg/l）。SHF膜在3 l/h UF和4 l/h UF下的筛分系数分别为72.2%和68.8%。与SHF膜的4.4-5.1 g/天相比，用常规膜去除的肌红蛋白的量为1.1 g/天。SHF膜的清除率高达56.4 l/天，并在48小时内将血清肌红蛋白浓度从> 100，000 μg/l降至16，542 μg/l。SHF血液滤过对肌红蛋白的清除率比常规血液滤过高得多，它可能为肌红蛋白尿性急性肾功能衰竭的治疗提供一种潜在的方式。
To test the ability of a novel super high-flux (SHF) membrane with a larger pore size to clear myoglobin from serum. The intensive care unit of a university teaching hospital. A patient with serotonin syndrome complicated by severe rhabodomyolysis and oliguric acute renal failure Initially continuous veno-venous hemofiltration was performed at 2 l/hour ultrafiltration (UF) with a standard polysulphone 1.4 m2 membrane (cutoff point, 20 kDa), followed by continuous veno-venous hemofiltration with a SHF membrane (cutoff point, 100 kDa) at 2 l/hour UF, then at 3 l/hour UF and then at 4 l/hour UF, in an attempt to clear myoglobin. The myoglobin concentration in the ultrafiltrate at 2 l/hour exchange was at least five times greater with the SHF membrane than with the conventional membrane (>100,000 μg/l versus 23,003 μg/l). The sieving coefficients with the SHF membrane at 3 l/hour UF and 4 l/hour UF were 72.2% and 68.8%, respectively. The amount of myoglobin removed with the conventional membrane was 1.1 g/day compared with 4.4–5.1 g/day for the SHF membrane. The SHF membrane achieved a clearance of up to 56.4 l/day, and achieved a reduction in serum myoglobin concentration from >100,000 μg/l to 16,542 μg/l in 48 hours. SHF hemofiltration achieved a much greater clearance of myoglobin than conventional hemofiltration, and it may provide a potential modality for the treatment of myoglobinuric acute renal failure.
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影响因子：
1.7
作者：
Lee, WCR;Uchino, S;Bellomo, R
通讯作者：
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作者：
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