Electrical recording from hearts with flexible nanowire device arrays.
Electrical recording from hearts with flexible nanowire device arrays.
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DOI：
10.1021/nl900096z
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发表时间：
2009-02
期刊：
影响因子：
10.8
通讯作者：
Lieber CM
中科院分区：
文献类型：
--
作者：
Timko BP;Cohen-Karni T;Yu G;Qing Q;Tian B;Lieber CM
我们证明了在平面和柔性聚合物衬底上制造的纳米线场效应晶体管（NWFET）阵列可以在平面和弯曲构象中再现地与自发跳动的胚胎鸡心脏连接。玻璃微电极和NWFET器件的同步记录表明，NWFET的电导变化与心脏的跳动同步。尽管电压校准信号（4-6 mV）相对恒定，且通常比微电极阵列记录的信号大，但与敲打相关的电导变化可以通过器件灵敏度进行实质性调整。NWFET阵列的多路记录产生了高空间分辨率的信号在心肌中的传播时间。透明和灵活的NWFET芯片还可以同时进行电记录和光学登记，以三维构象的器件到心脏表面，这是平面微器件不可能做到的。同时光学成像和电记录的能力也可以用于在细胞水平上将设备注册到心肌的特定区域，更一般地说，在越来越灵活的塑料和/或生物聚合物基板上制造的NWFET阵列有潜力成为从其他组织/器官样本进行电记录的独特工具或作为强大的植入物。
We show that nanowire field-effect transistor (NWFET) arrays fabricated on both planar and flexible polymeric substrates can be reproducibly interfaced with spontaneously-beating embryonic chicken hearts in both planar and bent conformations. Simultaneous recordings from glass microelectrode and NWFET devices show that NWFET conductance variations are synchronized with the beating heart. The conductance change associated with beating can be tuned substantially by device sensitivity, although the voltage-calibrated signals, 4–6 mV, are relatively constant and typically larger than signals recorded by microelectrode arrays. Multiplexed recording from NWFET arrays yielded signal propagation times across the myocardium with high spatial resolution. The transparent and flexible NWFET chips also enable simultaneous electrical recording and optical registration of devices to heart surfaces in three-dimensional conformations not possible with planar microdevices. The capability of simultaneous optical imaging and electrical recording also could be used to register devices to a specific region of the myocardium at the cellular level, and more generally, NWFET arrays fabricated on increasingly flexible plastic and/or biopolymer substrates have the potential to become unique tools for electrical recording from other tissue/organ samples or as powerful implants.
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影响因子：
10.8
作者：
McAlpine, MC;Friedman, RS;Lieber, CM
通讯作者：
Lieber, CM
影响因子：
5.5
作者：
Fedorov, Vadim V.;Lozinsky, Ilya T.;Efimov, Igor R.
通讯作者：
Efimov, Igor R.
影响因子：
--
作者：
Lu, ZJ;Pereverzev, A;Schneider, T
通讯作者：
Schneider, T
影响因子：
14.8
作者：
Patolsky, Fernando;Zheng, Gengfeng;Lieber, Charles M.
通讯作者：
Lieber, Charles M.
影响因子：
2.5
作者：
Rothenberg, F;Watanabe, M;Rosenbaum, D
通讯作者：
Rosenbaum, D