Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis.
Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis.
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DOI：
10.1021/ct4008603
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发表时间：
2014-02-11
影响因子：
5.5
通讯作者：
Amaro, Rommie E.
中科院分区：
文献类型：
--
作者：
Van Wart, Adam T.;Durrant, Jacob;Votapka, Lane;Amaro, Rommie E.
Allostery can occur by way of subtle cooperation among protein residues (e.g., amino acids) even in the absence of large conformational shifts. Dynamical network analysis has been used to model this cooperation, helping to computationally explain how binding to an allosteric site can impact the behavior of a primary site many ångstroms away. Traditionally, computational efforts have focused on the most optimal path of correlated motions leading from the allosteric to the primary active site. We present a program called Weighted Implementation of Suboptimal Paths (WISP) capable of rapidly identifying additional suboptimal pathways that may also play important roles in the transmission of allosteric signals. Aside from providing signal redundancy, suboptimal paths traverse residues that, if disrupted through pharmacological or mutational means, could modulate the allosteric regulation of important drug targets. To demonstrate the utility of our program, we present a case study describing the allostery of HisH-HisF, an amidotransferase from T. maritima thermotiga. WISP and its VMD-based graphical user interface (GUI) can be downloaded from .
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影响因子：
5.8
作者：
Eargle, John;Luthey-Schulten, Zaida
通讯作者：
Luthey-Schulten, Zaida
影响因子：
4.4
作者：
Andricioaei, I;Karplus, M
通讯作者：
Karplus, M
DOI：
10.1016/0263-7855(95)00003-o
发表时间：
1995-06-01
期刊：
JOURNAL OF MOLECULAR GRAPHICS
影响因子：
--
作者：
COUCH, GS;PETTERSEN, EF;FERRIN, TE
通讯作者：
FERRIN, TE
影响因子：
5.7
作者：
Long, Dong;Brueschweiler, Rafael
通讯作者：
Brueschweiler, Rafael
影响因子：
2
作者：
COOPER, A;DRYDEN, DTF
通讯作者：
DRYDEN, DTF