Olfactory neuromodulation of motion vision circuitry in Drosophila.
Olfactory neuromodulation of motion vision circuitry in Drosophila.
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DOI：
10.1016/j.cub.2014.12.012
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发表时间：
2015-02-16
期刊：
影响因子：
9.2
通讯作者：
Frye, Mark A.
中科院分区：
文献类型：
--
作者：
Wasserman, Sara M.;Aptekar, Jacob W.;Lu, Patrick;Jade Nguyen;Wang, Austin L.;Keles, Mehmet F.;Grygoruk, Anna;Krantz, David E.;Larsen, Camilla;Frye, Mark A.
众所周知，知觉很大程度上是多感官的。通常通过触觉、视觉和听觉等方式来检测从空间中的共同点发出的刺激；并由空间对齐的脑组织图进行处理。然而，不共享空间刺激域但对于嘈杂环境中的鲁棒感知至关重要的模式之间的神经相互作用仍然没有被表征。黑腹果蝇靠导航食物气味羽流为生。气味可以增强稳定凝视的视运动反射的强度，使动物保持在看不见的羽流中对齐，从而促进自由飞行中的气味定位。在这里，我们研究跨模式行为相互作用的细胞机制。我们描述了小叶板的广域运动选择性中间神经元，其与较大果蝇中发现的“Hx”神经元具有解剖学和生理学相似性。果蝇 Hx 通过配对气味表现出跨模式的视觉反应增强，并且小叶板的突触前输入是行为气味跟踪所必需的，但它们本身并不是气味调制的目标，邻近的广域“HSE”神经元也不是。飞行开始时介导视觉反应增强的章鱼胺能神经元也表现出气味诱发的钙调节，并与 Hx 树突形成连接。最后，恢复携带所有胺能信号无效突变的动物八多巴胺能神经元内的突触小泡运输足以恢复气味追踪行为。这些结果首次证明了果蝇气味定位所需的视觉嗅觉整合的细胞机制，这可能代表了跨类群的适应性多感官相互作用。气味跟踪行为需要小视场运动检测神经元 定向广视场中间神经元 (Hx) 的反应随着成对气味的增加而增加 气味会激活支配视觉系统的八巴胺能 (OA) 神经元 OA 细胞接触 Hx； OA 囊泡运输是气味追踪行为所必需的 Wasserman 等人。报告称，果蝇中的定向选择性宽场运动检测神经元（Hx）增加了配对气味的响应增益。这种多模式相互作用依赖于章鱼胺能神经元的囊泡运输，章鱼胺能神经元本身对气味做出反应并使细胞与 Hx 接触。
It is well established that perception is largely multisensory; often served by modalities such as touch, vision, and hearing that detect stimuli emanating from a common point in space; and processed by brain tissue maps that are spatially aligned. However, the neural interactions among modalities that share no spatial stimulus domain yet are essential for robust perception within noisy environments remain uncharacterized. Drosophila melanogaster makes its living navigating food odor plumes. Odor acts to increase the strength of gaze-stabilizing optomotor reflexes to keep the animal aligned within an invisible plume, facilitating odor localization in free flight. Here, we investigate the cellular mechanism for cross-modal behavioral interactions. We characterize a wide-field motion-selective interneuron of the lobula plate that shares anatomical and physiological similarities with the “Hx” neuron identified in larger flies. Drosophila Hx exhibits cross-modal enhancement of visual responses by paired odor, and presynaptic inputs to the lobula plate are required for behavioral odor tracking but are not themselves the target of odor modulation, nor is the neighboring wide-field “HSE” neuron. Octopaminergic neurons mediating increased visual responses upon flight initiation also show odor-evoked calcium modulations and form connections with Hx dendrites. Finally, restoring synaptic vesicle trafficking within the octopaminergic neurons of animals carrying a null mutation for all aminergic signaling is sufficient to restore odor-tracking behavior. These results are the first to demonstrate cellular mechanisms underlying visual-olfactory integration required for odor localization in fruit flies, which may be representative of adaptive multisensory interactions across taxa. Small-field motion detection neurons are required for odor-tracking behavior Responses of a directional wide-field interneuron (Hx) increase with paired odor Odor activates octopaminergic (OA) neurons that innervate the visual system OA cells contact Hx; OA vesicle trafficking is required for odor-tracking behavior Wasserman et al. report that a directionally selective wide-field motion-detecting neuron (Hx) in the fly increases response gain with paired odor. This multimodal interaction is dependent upon vesicle trafficking from octopaminergic neurons, which are themselves responsive to odor and make cell-cell contact with Hx.
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2.5
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