Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus.
Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus.
复制标题
DOI：
10.1371/journal.pone.0088371
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Targher G
中科院分区：
文献类型：
--
作者：
Bonapace S;Valbusa F;Bertolini L;Pichiri I;Mantovani A;Rossi A;Zenari L;Barbieri E;Targher G
最近的流行病学数据表明，非酒精性脂肪性肝病（NAFLD）与主动脉瓣硬化（AVS）密切相关，AVS是非糖尿病和2型糖尿病患者不良心血管结局的新危险因素。到目前为止，还没有人调查过2型糖尿病患者NAFLD和AVS之间的关系，而2型糖尿病患者中这两种疾病的患病率很高。我们连续招募了180名无缺血性心脏病、瓣膜性心脏病、肝脏疾病或过度饮酒的2型糖尿病患者。所有参与者均通过肝脏超声诊断NAFLD，而AVS则通过常规超声心动图确定。在整个样本中，120例（66.7%）患者患有NAFLD， 53例（29.4%）患者患有AVS。没有患者出现主动脉狭窄。NAFLD与AVS患病率增加密切相关（优势比[OR] 2.79, 95% CI 1.3-6.1, p<0.01）。调整年龄、性别、糖尿病病程、糖尿病治疗、体重指数、吸烟、饮酒、高血压、血脂异常、糖化血红蛋白和肾小球滤过率并没有减弱NAFLD与AVS患病率之间的强相关性（调整比值比3.04,95% CI 1.3-7.3, p = 0.01）。我们的研究结果首次证明了2型糖尿病患者NAFLD和AVS之间存在积极和独立的关联。
Recent epidemiological data suggest that non-alcoholic fatty liver disease (NAFLD) is closely associated with aortic valve sclerosis (AVS), an emerging risk factor for adverse cardiovascular outcomes, in nondiabetic and type 2 diabetic individuals. To date, nobody has investigated the association between NAFLD and AVS in people with type 2 diabetes, a group of individuals in which the prevalence of these two diseases is high. We recruited 180 consecutive type 2 diabetic patients without ischemic heart disease, valvular heart disease, hepatic diseases or excessive alcohol consumption. NAFLD was diagnosed by liver ultrasonography whereas AVS was determined by conventional echocardiography in all participants. In the whole sample, 120 (66.7%) patients had NAFLD and 53 (29.4%) had AVS. No patients had aortic stenosis. NAFLD was strongly associated with an increased risk of prevalent AVS (odds ratio [OR] 2.79, 95% CI 1.3–6.1, p<0.01). Adjustments for age, sex, duration of diabetes, diabetes treatment, body mass index, smoking, alcohol consumption, hypertension, dyslipidemia, hemoglobin A1c and estimated glomerular filtration rate did not attenuate the strong association between NAFLD and risk of prevalent AVS (adjusted-OR 3.04, 95% CI 1.3–7.3, p = 0.01). Our results provide the first demonstration of a positive and independent association between NAFLD and AVS in patients with type 2 diabetes mellitus.
登录
查看更多内容
影响因子：
25.7
作者：
Hallsworth, Kate;Hollingsworth, Kieren G.;Trenell, Michael I.
通讯作者：
Trenell, Michael I.
影响因子：
5.7
作者：
Targher, Giovanni;Byrne, Christopher D.
通讯作者：
Byrne, Christopher D.
影响因子：
7.1
作者：
Ding, Jingzhong;Hsu, Fang-Chi;Carr, J. Jeffrey
通讯作者：
Carr, J. Jeffrey
影响因子：
3.7
作者：
Targher, Giovanni;Valbusa, Filippo;Byrne, Christopher D.
通讯作者：
Byrne, Christopher D.
影响因子：
37.8
作者：
Rosito, Guido A.;Massaro, Joseph M.;Fox, Caroline S.
通讯作者：
Fox, Caroline S.