Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis.
Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis.
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长链非编码RNA：预测肿瘤侵袭和转移的潜在新生物标志物
DOI：
10.1186/s12943-016-0545-z
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发表时间：
2016-09-29
期刊：
影响因子：
37.3
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Jiang C;Li X;Zhao H;Liu H
长链非编码RNA（lncRNA）在恶性肿瘤中起重要作用。事实上，癌症的许多标志定义肿瘤细胞的恶性表型由lncRNA控制。尽管越来越多的研究强调了它们在癌症中的重要性，但尚未对各种癌症类型中的转移相关lncRNA进行系统综述。因此，本文将重点介绍与肿瘤转移相关的关键lncRNA，并通过对以往研究的回顾，概述其在肿瘤组织中的表达状况，以期对近年来与肿瘤转移相关的lncRNA的研究成果进行总结。应用Medline、EMBASE和PubMed数据库对与肿瘤侵袭转移密切相关的lncRNA进行研究。迄今为止，已发现大量lncRNA具有重要的生物学功能。本文根据lncRNA在肿瘤中的不同特点，将其大致分为促进肿瘤侵袭转移、负调节肿瘤转移和具有双重调节作用三类。本研究可能为进一步研究癌症进展机制和未来基于lncRNA的临床应用奠定基础。
Long non-coding RNAs (lncRNAs) play important roles in malignant neoplasia. Indeed, many hallmarks of cancer define that the malignant phenotype of tumor cells are controlled by lncRNAs. Despite a growing number of studies highlighting their importance in cancer, there has been no systematic review of metastasis-associated lncRNAs in various cancer types. Accordingly, we focus on the key metastasis-related lncRNAs and outline their expression status in cancer tissues by reviewing the previous stuides, in order to summarize the nowadays research achivements for lncRNAs related to cancer metastasis. Medline, EMBASE, as well as PubMed databases were applied to study lncRNAs which were tightly associated with tumor invasion and metastasis. Up to now, a substantial number of lncRNAs have been found to have important biological functions. In this review, according to their various features in cancer, lncRNAs were roughly divided into three categories: promoting tumor invasion and metastasis, negative regulation of tumor metastasis and with dual regulatory roles. The present studies may establish the foundation for both further research on the mechanisms of cancer progression and future lncRNA-based clinical applications.
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