The functional role of long non-coding RNA in human carcinomas.

The functional role of long non-coding RNA in human carcinomas.
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DOI:
10.1186/1476-4598-10-38
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发表时间:
2011-04-13
期刊:
影响因子:
37.3
通讯作者:
Lam WL
Lam WL
中科院分区:
医学1区
文献类型:
--
作者:
Gibb EA;Brown CJ;Lam WL

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长非编码RNA(LncRNAs)是癌症研究中的新成员,在致癌和肿瘤抑制途径中都显示出潜在的作用。这些新基因经常在多种人类癌症中异常表达,但绝大多数的生物学功能仍不清楚。最近,描述这些RNA物种功能的分子机制的证据已经开始积累,为深入了解它们在肿瘤发生中可能扮演的功能角色提供了洞察力。在这篇综述中,我们强调了lncRNAs在人类癌症中的新的功能作用。
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.
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