Adipokines and obesity are associated with colorectal polyps in adult males: a cross-sectional study.
Adipokines and obesity are associated with colorectal polyps in adult males: a cross-sectional study.
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DOI：
10.1371/journal.pone.0085939
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fenton JI
中科院分区：
文献类型：
--
作者：
Comstock SS;Hortos K;Kovan B;McCaskey S;Pathak DR;Fenton JI
肥胖会增加患结肠癌的风险。众所周知，大多数结直肠癌是由腺瘤性息肉发展而来的。然而，肥胖和脂肪因子对结肠息肉形成的影响尚不清楚。为了确定BMI、腰围或脂肪因子是否与男性结肠息肉相关，在结肠镜检查时招募了126名无症状男性（48-65岁），并收集了人体测量和血液。使用多分类logistic回归确定息肉数量（0或≥3）和息肉类型（无息肉、增生性息肉、管状腺瘤）的比值比。我们研究中41%的男性肥胖（BMI ≥30）。肥胖个体有≥3个息肉的几率是瘦个体（BMI<25）的6.5倍（CI：1.3-33.0）。此外，相对于瘦个体，肥胖个体患管状腺瘤的可能性是无息肉的7.8倍（CI：2.0-30.8）。随着BMI类别的增加，参与者患管状腺瘤的可能性是没有息肉的2.9倍（CI：1.5-5.4）。血清瘦素、IP-10和TNF-α与管状腺瘤的存在显著相关。血清瘦素和IP-10与≥3个息肉的可能性增加显著相关，TNF-α显示出趋势（p = 0.09）。 肥胖男性更有可能至少有三个息肉和腺瘤。这项横断面研究提供的证据表明，结肠镜检查应建议肥胖，白色男性。
Obesity increases the risk of colon cancer. It is also known that most colorectal cancers develop from adenomatous polyps. However, the effects of obesity and adipokines on colonic polyp formation are unknown. To determine if BMI, waist circumference or adipokines are associated with colon polyps in males, 126 asymptomatic men (48–65 yr) were recruited at time of colonoscopy, and anthropometric measures as well as blood were collected. Odds ratios were determined using polytomous logistic regression for polyp number (0 or ≥3) and polyp type (no polyp, hyperplastic polyp, tubular adenoma). 41% of the men in our study were obese (BMI ≥30). The odds of an obese individual having ≥3 polyps was 6.5 (CI: 1.3–33.0) times greater than those of a lean (BMI<25) individual. Additionally, relative to lean individuals, obese individuals were 7.8 (CI: 2.0–30.8) times more likely to have a tubular adenoma than no polyp. As BMI category increased, participants were 2.9 (CI: 1.5–5.4) times more likely to have a tubular adenoma than no polyps. Serum leptin, IP-10 and TNF-α were significantly associated with tubular adenoma presence. Serum leptin and IP-10 were significantly associated with increased likelihood of ≥3 polyps, and TNF-α showed a trend (p = 0.09). Obese men are more likely to have at least three polyps and adenomas. This cross-sectional study provides evidence that colonoscopy should be recommended for obese, white males.
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影响因子：
120.7
作者：
Hedley, AA;Ogden, CL;Flegal, KM
通讯作者：
Flegal, KM
影响因子：
5
作者：
Fu, Zhenming;Shrubsole, Martha J.;Zheng, Wei
通讯作者：
Zheng, Wei
根据荟萃分析，体重指数会增加结直肠腺瘤的风险
影响因子：
29.4
作者：
Ben, Qiwen;An, Wei;Li, Zhaoshen
通讯作者：
Li, Zhaoshen
影响因子：
3.8
作者：
Bobe, Gerd;Murphy, Gwen;Cross, Amanda J.
通讯作者：
Cross, Amanda J.
影响因子：
3.8
作者：
Fenton, JI;Hord, NG;Hursting, SD
通讯作者：
Hursting, SD