Diurnal cortisol rhythms among Latino immigrants in Oregon, USA.
Diurnal cortisol rhythms among Latino immigrants in Oregon, USA.
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DOI：
10.1186/1880-6805-31-19
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发表时间：
2012-06-25
影响因子：
3.1
通讯作者：
Snodgrass JJ
中科院分区：
文献类型：
--
作者：
Squires EC;McClure HH;Martinez CR Jr;Eddy JM;Jiménez RA;Isiordia LE;Snodgrass JJ
最常用的压力生物标志物之一是皮质醇，这是一种由肾上腺释放的糖皮质激素，是生理压力反应的核心。游离皮质醇可以在唾液中测量，并且已经成为测量下丘脑-垂体-肾上腺轴功能的应激研究中选择的生物标志物。慢性心理社会应激可导致下丘脑-垂体-肾上腺轴功能失调，导致皮质醇昼夜变化异常。关于美国拉丁裔人口客观测量的压力和健康状况知之甚少，但这可能是理解拉丁裔和白人之间存在的健康差异的重要因素。本研究旨在测量皮质醇配置文件之间的拉丁美洲移民农场工人在俄勒冈州（美国），并比较定量和定性的措施，在这个人口的压力。我们的结果表明，两天内平均皮质醇AUCg（相对于地面的曲线下面积）没有性别差异（平均AUCg;男性= 1.38，女性= 1.60; P = 0.415）。男性的AUCg 1（第1天AUCg）和AvgAUCg与年龄呈显著负相关（P<0.05）。女性AUCg 1与体重（P<0.05）、腰围（P<0.01）和腰高比（P<0.05）呈负相关，这与皮质醇与腰高比之间的预期关系相反，可能表明下丘脑-垂体-肾上腺轴失调。在男性中，在美国的时间越长，年龄越大，移民到美国的时间越长，平均AUC越大。在女性中，较高的生活方式不协调与较高的AvgAUCg显著相关。虽然是初步的，这些结果表明，慢性心理社会压力在这一人群的健康风险中起着重要作用。
One of the most commonly used stress biomarkers is cortisol, a glucocorticoid hormone released by the adrenal glands that is central to the physiological stress response. Free cortisol can be measured in saliva and has been the biomarker of choice in stress studies measuring the function of the hypothalamic-pituitary-adrenal axis. Chronic psychosocial stress can lead to dysregulation of hypothalamic-pituitary-adrenal axis function and results in an abnormal diurnal cortisol profile. Little is known about objectively measured stress and health in Latino populations in the United States, yet this is likely an important factor in understanding health disparities that exist between Latinos and whites. The present study was designed to measure cortisol profiles among Latino immigrant farmworkers in Oregon (USA), and to compare quantitative and qualitative measures of stress in this population. Our results indicate that there were no sex differences in average cortisol AUCg (area under the curve with respect to the ground) over two days (AvgAUCg; males = 1.38, females = 1.60; P = 0.415). AUCg1 (Day 1 AUCg) and AvgAUCg were significantly negatively associated with age in men (P<0.05). AUCg1 was negatively associated with weight (P<0.05), waist circumference (P<0.01) and waist-to-stature ratio (P<0.05) in women, which is opposite of the expected relationship between cortisol and waist-to-stature ratio, possibly indicating hypothalamic-pituitary-adrenal axis dysregulation. Among men, more time in the United States and immigration to the United States at older ages predicted greater AvgAUCg. Among women, higher lifestyle incongruity was significantly related to greater AvgAUCg. Although preliminary, these results suggest that chronic psychosocial stress plays an important role in health risk in this population.
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