Bone marrow from children in relapse with pre-B acute lymphoblastic leukemia proliferates and disseminates rapidly in scid mice.
Bone marrow from children in relapse with pre-B acute lymphoblastic leukemia proliferates and disseminates rapidly in scid mice.
复制标题
患有前 B 型急性淋巴细胞白血病复发的儿童的骨髓在 scid 小鼠中迅速增殖和传播。
DOI：
10.1182/blood.v78.11.2973.bloodjournal78112973
复制
发表时间：
1991
期刊：
影响因子：
20.3
通讯作者：
Robert A. Phillips
中科院分区：
文献类型：
--
作者：
S. Kamel;Michelle Letarte;M. Doedens;Adonna Greaves;Barbara Murdoch;T. Grunberger;T. Lapidot;Paul Thorner;Melvin H. Freedman;Robert A. Phillips
将诊断或复发的前B急性淋巴细胞白血病（pre-B ALL）患者的骨髓样本移植到scid小鼠中，以确定这些新鲜获得的白血病细胞是否可以在体内增殖，以及它们在体内生长特性是否有任何差异。在诊断后13个月内复发的三名患者的细胞在小鼠骨髓、脾脏和胸腺中迅速增殖，侵入外周器官，并导致动物在4至16周内发病和死亡。来自两名在诊断后3.5年复发的患者的细胞生长速度比早期复发样本慢得多，需要长达30周才能渗透到受体小鼠的骨髓中。相反，在scid小鼠中，移植了从三个尚未复发的患者身上获得的诊断细胞后，白血病细胞不存在或检测到少量。这些结果表明，预后不良的侵袭性淋巴细胞白血病患者的白血病细胞在scid小鼠中增殖的能力增强。
Bone marrow samples from patients with pre-B acute lymphoblastic leukemia (pre-B ALL), either at diagnosis or at relapse, were transplanted into scid mice to determine whether these freshly obtained leukemic cells could proliferate in vivo and whether there were any differences in their in vivo growth characteristics. Cells from three patients who relapsed within 13 months of diagnosis proliferated rapidly in the murine bone marrow, spleen, and thymus, invaded peripheral organs, and resulted in morbidity and mortality of the animals within 4 to 16 weeks. Cells from two patients who relapsed 3.5 years after diagnosis grew much slower than the early relapse samples, taking up to 30 weeks to infiltrate the bone marrow of recipient mice. In contrast, leukemic cells were absent or were detected at low numbers in scid mice transplanted with cells obtained at diagnosis from three patients who have not yet relapsed. These results show an increased ability of leukemic cells from patients with aggressive lymphoblastic leukemia of poor prognosis to proliferate in scid mice.
登录
查看更多内容
影响因子：
56.9
作者：
MCCUNE, JM;NAMIKAWA, R;WEISSMAN, IL
通讯作者：
WEISSMAN, IL
影响因子：
20.3
作者：
Richard E. Champlin;R. Gale
通讯作者：
Richard E. Champlin;R. Gale
DOI：
10.1056/nejm199008163230705
发表时间：
1990-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Masao Yamada;R. Wasserman;Beverly J. Lange;B. A. Reichard;R. Womer;Giovanni Rovera
通讯作者：
Masao Yamada;R. Wasserman;Beverly J. Lange;B. A. Reichard;R. Womer;Giovanni Rovera
免疫缺陷小鼠中人髓系白血病细胞的增殖和分化：电子显微镜和细胞化学。
影响因子：
20.3
作者：
Machado,EA;Gerard,DA;Lozzio,CB;Lozzio,BB;Mitchell,JR;Golde,DW
通讯作者：
Golde,DW