Analysis of Cerebral Aneurysm Wall Tension and Enhancement Using Finite Element Analysis and High-Resolution Vessel Wall Imaging.
Analysis of Cerebral Aneurysm Wall Tension and Enhancement Using Finite Element Analysis and High-Resolution Vessel Wall Imaging.
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DOI：
10.3389/fneur.2021.764063
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发表时间：
2021
影响因子：
3.4
通讯作者：
Hasan D
中科院分区：
文献类型：
--
作者：
Galloy AE;Raghuram A;Nino MA;Varon Miller A;Sabotin R;Osorno-Cruz C;Samaniego EA;Raghavan SML;Hasan D
颅内动脉瘤的生物力学计算模拟已经成为预测导致动脉瘤生长和破裂的不稳定特征的有前途的方法。动脉瘤行为的血流动力学分析有助于研究动脉瘤形状、形态、流动模式特征与动脉瘤壁增殖或降解之间的复杂关系。有限元分析结合高分辨率血管壁成像可以更深入地了解动脉瘤形态与壁行为的确切关系，以及壁增强是否可以描述这种现象。在对23例未破裂动脉瘤的回顾性分析中，使用各向同性、均质三阶多项式材料模型进行了有限元分析。在2D多平面视图上量化动脉瘤壁增强，14个动脉瘤被归类为增强（CRstalk≥0.6），9个被归类为非增强。增强动脉瘤的第95百分位数壁张力（μ = 0.77 N/cm）显著高于非增强动脉瘤（μ = 0.42 N/cm，p < 0.001）。壁增强仍然是壁张力的重要预测因素，同时考虑了动脉瘤大小的影响（p = 0.046）。在定性比较中，低壁张力区域集中在动脉瘤泡周围。形态不规则的动脉瘤可能显示低壁张力区域增加。有限元分析在颅内动脉瘤中的生物学意义尚不清楚，但可能会提供进一步了解水泡形成和动脉瘤破裂的复杂过程。
Biomechanical computational simulation of intracranial aneurysms has become a promising method for predicting features of instability leading to aneurysm growth and rupture. Hemodynamic analysis of aneurysm behavior has helped investigate the complex relationship between features of aneurysm shape, morphology, flow patterns, and the proliferation or degradation of the aneurysm wall. Finite element analysis paired with high-resolution vessel wall imaging can provide more insight into how exactly aneurysm morphology relates to wall behavior, and whether wall enhancement can describe this phenomenon. In a retrospective analysis of 23 unruptured aneurysms, finite element analysis was conducted using an isotropic, homogenous third order polynomial material model. Aneurysm wall enhancement was quantified on 2D multiplanar views, with 14 aneurysms classified as enhancing (CRstalk≥0.6) and nine classified as non-enhancing. Enhancing aneurysms had a significantly higher 95th percentile wall tension (μ = 0.77 N/cm) compared to non-enhancing aneurysms (μ = 0.42 N/cm, p < 0.001). Wall enhancement remained a significant predictor of wall tension while accounting for the effects of aneurysm size (p = 0.046). In a qualitative comparison, low wall tension areas concentrated around aneurysm blebs. Aneurysms with irregular morphologies may show increased areas of low wall tension. The biological implications of finite element analysis in intracranial aneurysms are still unclear but may provide further insights into the complex process of bleb formation and aneurysm rupture.
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影响因子：
2.8
作者：
Larsen N;Flüh C;Saalfeld S;Voß S;Hille G;Trick D;Wodarg F;Synowitz M;Jansen O;Berg P
通讯作者：
Berg P
DOI：
10.3174/ajnr.a4358
发表时间：
2015-09
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Cebral JR;Duan X;Chung BJ;Putman C;Aziz K;Robertson AM
通讯作者：
Robertson AM
影响因子：
4.8
作者：
Backes, Daan;Hendrikse, Jeroen;Vergouwen, Mervyn D. I.
通讯作者：
Vergouwen, Mervyn D. I.
影响因子：
6.1
作者：
Polzer, Stanislav;Kracik, Jan;Raghavan, Madhavan L.
通讯作者：
Raghavan, Madhavan L.
影响因子：
8.3
作者：
Rahman, Maryam;Smietana, Janel;Mocco, J.
通讯作者：
Mocco, J.