Endoplasmic reticulum is at the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in the pathogenesis of diabetes mellitus.
Endoplasmic reticulum is at the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in the pathogenesis of diabetes mellitus.
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内质网处于自噬、炎症和凋亡信号通路的十字路口并参与糖尿病的发病机制
DOI：
10.1155/2013/193461
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发表时间：
2013
影响因子：
4.3
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Su J;Zhou L;Kong X;Yang X;Xiang X;Zhang Y;Li X;Sun L
糖尿病（DM）是一种慢性代谢性疾病，其发病率在世界范围内呈上升趋势。内质网（ER）是细胞功能的核心组成部分，参与蛋白质折叠和运输，脂质合成和钙稳态的维持。内质网也是细胞内和细胞外应激的传感器，因此参与监测和维持细胞内稳态。因此，内质网是环境信号与细胞生物学功能相互作用的一个位点。内质网与自噬、炎症和细胞凋亡密切相关，最近的证据表明，这些过程与糖尿病及其并发症的发病机制有关。因此，内质网被认为是多种应激反应的交叉点，在包括糖尿病在内的代谢相关疾病中发挥着重要作用。在这里，我们综述了内质网与糖尿病自噬、炎症和凋亡的关系，以更好地了解该疾病的分子机制。
Diabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide. The endoplasmic reticulum (ER) is a central component of cellular functions and is involved in protein folding and trafficking, lipid synthesis, and maintenance of calcium homeostasis. The ER is also a sensor of both intra- and extracellular stress and thus participates in monitoring and maintaining cellular homeostasis. Therefore, the ER is one site of interaction between environmental signals and a cell's biological function. The ER is tightly linked to autophagy, inflammation, and apoptosis, and recent evidence suggests that these processes are related to the pathogenesis of DM and its complications. Thus, the ER has been considered an intersection integrating multiple stress responses and playing an important role in metabolism-related diseases including DM. Here, we review the relationship between the ER and autophagy, inflammation, and apoptosis in DM to better understand the molecular mechanisms of this disease.
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