Assessing the effects of endocrine disruptors in the National Children's Study.
Assessing the effects of endocrine disruptors in the National Children's Study.
复制标题
评估国家儿童研究中内分泌干扰物的影响。
DOI：
10.1289/ehp.5799
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发表时间：
2003-10
影响因子：
10.4
通讯作者：
Droller, DBJ
中科院分区：
文献类型：
--
作者：
Landrigan, P;Garg, A;Droller, DBJ
儿童特别容易受到环境中有毒化学物质的影响。儿童面临接触风险的环境毒物包括内分泌干扰物 (ED)，即能够干扰荷尔蒙信号系统的化学物质。 ED 可能会改变大脑、垂体、性腺、甲状腺和内分泌系统其他组成部分的反馈回路。它们会影响发育。 ED 的影响已在野生动物种群、实验性暴露的动物中得到描述，在人类中的影响程度更为有限。 ED 的作用机制越来越多地被阐明，并且人们开始探索表达 ED 不同易感性的遗传多态性。据推测，在子宫内和儿童早期接触 ED 可能是（至少部分）精液质量下降的原因；生殖器官先天性畸形（例如尿道下裂）的发生率增加；睾丸癌的发病率增加；并加速女性青春期的开始。国家儿童研究（NCS）将提供一个独特的机会，在大型前瞻性多年流行病学调查的背景下检验这些假设的有效性。在 NCS 中，有必要评估一系列假定的天然和合成 ED 暴露情况，评估 ED 暴露可能导致的结果，检查 ED 与遗传多态性之间的潜在相互作用，并寻找生命早期 ED 暴露与整个生命周期的内分泌、生殖、神经行为和其他结果之间的联系。
Children are uniquely vulnerable to toxic chemicals in the environment. Among the environmental toxicants to which children are at risk of exposure are endocrine disruptors (EDs)--chemicals that have the capacity to interfere with hormonal signaling systems. EDs may alter feedback loops in the brain, pituitary, gonads, thyroid, and other components of the endocrine system. They can affect development. Effects of EDs have been described in wildlife populations, in animals exposed experimentally, and to a more limited extent in humans. Mechanisms of action of EDs are increasingly being elucidated, and genetic polymorphisms that convey differential susceptibility to EDs are beginning to be explored. It is hypothesized that in utero and early childhood exposures to EDs may be responsible, at least in part, for decreases in semen quality; increasing incidence of congenital malformations of the reproductive organs, such as hypospadias; increasing incidence of testicular cancer; and acceleration of onset of puberty in females. The National Children's Study (NCS) will provide a unique opportunity to test the validity of these hypotheses in the context of a large prospective multi-year epidemiologic investigation. It will be essential in the NCS to assess exposures to a range of putative natural and synthetic EDs, to assess outcomes possibly due to ED exposure, to examine the potential interplay between EDs and genetic polymorphisms, and to seek links between ED exposures in early life and endocrine, reproductive, neurobehavioral, and other outcomes throughout the life span.
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