Bone bonding in sintered hydroxyapatite combined with a new synthesized agent, TAK-778.
Bone bonding in sintered hydroxyapatite combined with a new synthesized agent, TAK-778.
复制标题
烧结羟基磷灰石与新型合成剂 TAK-778 的骨结合。
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
T. Nakamura
中科院分区：
文献类型：
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作者：
H. Kato;S. Nishiguchi;T. Furukawa;M. Neo;K. Kawanabe;K. Saito;T. Nakamura
我们研究了TAK-778（一种促进成骨细胞分化的新型合成3-苯并噻庚因衍生物）在兔胫骨中骨结合至烧结羟基磷灰石植入物的刺激作用。将由烧结羟基磷灰石制成的表面光滑的矩形板（15 x 10 x 2 mm）植入双侧家兔胫骨近端干骺端，将含TAK-778的缓释微胶囊填充到一侧肢体的髓腔中，将未处理的微胶囊填充到对侧肢体中，作为配对对照。在植入后4、8和16周，通过分离试验和不脱钙组织学检查评价骨-植入物界面的骨结合。两组的拉伸失效载荷均从4周增加至16周;然而，在植入后的每个时间点，TAK-778给药组的拉伸失效载荷均显著大于对照组。在组织学上，TAK-778处理的样本显示，与未处理的样本相比，主要在髓腔中的活性新骨形成更大，植入物与骨之间的结合更广泛。本研究的结果表明，向羟基磷灰石植入物中添加骨诱导性TAK-778可显著加速骨与植入物的沉积，并改善界面的结合过程。这将有助于在周围骨组织之间建立骨科陶瓷植入物的早期和更强的结合。
We studied the stimulatory effects of TAK-778, a new synthetic 3-benzothiepin derivative that promotes osteoblast differentiation, in bone bonding to sintered hydroxyapatite implants in rabbit tibiae. Smooth-surfaced rectangular plates (15 x 10 x 2 mm) made of sintered hydroxyapatite were implanted into the proximal metaphyses of bilateral rabbit tibiae, with TAK-778-containing sustained-release microcapsules packed into the medullary cavity in one limb and untreated microcapsules packed in the contralateral limb to serve as a paired control. At 4, 8, and 16 weeks after implantation, bone bonding at the bone-implant interfaces was evaluated by a detaching test and undecalcified histological examination. The tensile failure load increased from 4 to 16 weeks for both groups; however, the tensile failure load of the TAK-778-treated group was significantly greater than that of the control group at each interval after implantation. Histologically, the TAK-778-treated specimens showed greater active new bone formation mainly in the medullary cavity and more extensive bonding between the implant and bone than the untreated specimens. The results of this study suggest that adding osteoinductive TAK-778 to hydroxyapatite implants may significantly accelerate bone apposition to the implants and improve the bonding process at the interface. This would help to establish an earlier and stronger bonding of orthopedic ceramic implants between the surrounding bone tissue.
影响因子：
4.3
作者：
LYNCH, SE;BUSER, D;WILLIAMS, RC
通讯作者：
WILLIAMS, RC
通过转化生长因子-β 促进骨向内生长。
DOI：
10.2106/00004623-199508000-00001
发表时间：
1995
期刊：
The Journal of bone and joint surgery. American volume
影响因子：
--
作者：
Sumner,DR;Turner,TM;Purchio,AF;Gombotz,WR;Urban,RM;Galante,JO
通讯作者：
Galante,JO