A prospective study of organochlorines in adipose tissue and risk of non‑Hodgkin lymphoma.
A prospective study of organochlorines in adipose tissue and risk of non‑Hodgkin lymphoma.
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DOI：
10.1289/ehp.1103573
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发表时间：
2012-01
影响因子：
10.4
通讯作者：
Raaschou-Nielsen O
中科院分区：
文献类型：
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作者：
Bräuner EV;Sørensen M;Gaudreau E;LeBlanc A;Eriksen KT;Tjønneland A;Overvad K;Raaschou-Nielsen O
背景：有机氯暴露已被研究为非霍奇金淋巴瘤（NHL）的潜在危险因素，但结果不一致，这可能与有限的统计能力或不精确的暴露测量有关。目的：我们的目的是检查诊断前脂肪组织样本中有机氯浓度与NHL风险之间的关系。方法：我们进行了一项病例队列研究，在1993年至1997年期间纳入了57,053人的前瞻性丹麦队列。在队列中，我们在以人群为基础的全国丹麦癌症登记处确定了256名诊断为NHL的患者，并随机选择了256名亚队列患者。我们测量了登记时收集的脂肪组织中8种农药和10种多氯联苯（PCB）同系物的浓度。采用Cox回归模型分析18种有机氯与NHL之间的关系，调整体重指数。结果：二氯二苯三氯乙烷（DDT）、顺式非氯胺和氧氯丹浓度四分位数范围内增加的发生率比和置信区间（CI）分别为1.35 （95% CI: 1.10, 1.66）、1.13 （95% CI: 0.94, 1.36）和1.11 (95% CI: 0.89, 1.38)，基于分类模型的DDT和顺式非氯胺的剂量-反应趋势为单调的。男性的相对风险估计高于女性。相比之下，在NHL和多氯联苯之间没有发现明确的关联。结论：我们发现NHL的高风险与脂肪组织中DDT、顺式非氯胺和氧氯丹的高水平有关，但与多氯联苯无关。这是第一次在暴露评估中使用诊断前脂肪组织样本对有机氯和非霍霍性淋巴瘤进行研究，并提供了新的环境健康证据，证明这些有机氯会增加非霍霍性淋巴瘤的风险。
Background: Exposure to organochlorines has been examined as a potential risk factor for non-Hodgkin lymphoma (NHL), with inconsistent results that may be related to limited statistical power or to imprecise exposure measurements. Objective: Our purpose was to examine associations between organochlorine concentrations in prediagnostic adipose tissue samples and the risk of NHL. Methods: We conducted a case–cohort study using a prospective Danish cohort of 57,053 persons enrolled between 1993 and 1997. Within the cohort we identified 256 persons diagnosed with NHL in the population-based nationwide Danish Cancer Registry and randomly selected 256 subcohort persons. We measured concentrations of 8 pesticides and 10 polychlorinated biphenyl (PCB) congeners in adipose tissue collected upon enrollment. Associations between the 18 organochlorines and NHL were analyzed in Cox regression models, adjusting for body mass index. Results: Incidence rate ratios and confidence intervals (CIs) for interquartile range increases in concentrations of dichlorodiphenyltrichlorethane (DDT), cis-nonachlor, and oxychlordane were 1.35 (95% CI: 1.10, 1.66), 1.13 (95% CI: 0.94, 1.36), and 1.11 (95% CI: 0.89, 1.38), respectively, with monotonic dose–response trends for DDT and cis-nonachlor based on categorical models. The relative risk estimates were higher for men than for women. In contrast, no clear association was found between NHL and PCBs. Conclusion: We found a higher risk of NHL in association with higher adipose tissue levels of DDT, cis-nonachlor, and oxychlordane, but no association with PCBs. This is the first study of organochlorines and NHL using prediagnostic adipose tissue samples in the exposure assessment and provides new environmental health evidence that these organochlorines contribute to NHL risk.
影响因子：
10.4
作者：
Bräuner EV;Sørensen M;Gaudreau E;LeBlanc A;Eriksen KT;Tjønneland A;Overvad K;Raaschou-Nielsen O
通讯作者：
Raaschou-Nielsen O