Dissociation of detection and discrimination of pure tones following bilateral lesions of auditory cortex.
Dissociation of detection and discrimination of pure tones following bilateral lesions of auditory cortex.
复制标题
DOI：
10.1371/journal.pone.0044602
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Tramo MJ
中科院分区：
文献类型：
--
作者：
Dykstra AR;Koh CK;Braida LD;Tramo MJ
众所周知，外周听觉系统的损伤会导致音调检测缺陷，以及在宽频率范围内的音调和响度感知缺陷。然而，听觉皮层在频谱处理的这些基本方面，特别是在语言、音乐和环境声音感知方面，发挥了多大的关键作用，目前尚不清楚。最近的实验表明，初级听觉皮层对于人类在纯音频率识别中表现出的正常高感知敏锐度是必要的。本研究评估了听觉皮层是否在强度域发挥类似的作用，并比较了听觉皮层对强度加工的感觉和判别方面的贡献。我们测量了一组健康成年人和一名双侧听觉皮质完全或接近完全损伤的中年男性的纯音检测和纯音响度辨别的强度阈值。左耳和右耳的检测阈值分别为16和7 dB HL，在临床定义的正常范围内。相比之下，在1 kHz时，左耳的单耳响度识别强度阈值为6.5±2.1 dB，右耳为6.5±1.9 dB，远高于对照人群的平均值（左耳：1.6±0.22 dB；右耳：1.7±0.19 dB）。结果表明，听觉皮层在声音辨别方面降低了大约5分贝的刚刚明显的差异，但在安静环境下的音调检测方面却没有必要。本文综述了以往人类和旧世界猴子利用损伤效应、神经生理学和神经影像学方法研究听觉皮层在强度加工中的作用的实验。
It is well known that damage to the peripheral auditory system causes deficits in tone detection as well as pitch and loudness perception across a wide range of frequencies. However, the extent to which to which the auditory cortex plays a critical role in these basic aspects of spectral processing, especially with regard to speech, music, and environmental sound perception, remains unclear. Recent experiments indicate that primary auditory cortex is necessary for the normally-high perceptual acuity exhibited by humans in pure-tone frequency discrimination. The present study assessed whether the auditory cortex plays a similar role in the intensity domain and contrasted its contribution to sensory versus discriminative aspects of intensity processing. We measured intensity thresholds for pure-tone detection and pure-tone loudness discrimination in a population of healthy adults and a middle-aged man with complete or near-complete lesions of the auditory cortex bilaterally. Detection thresholds in his left and right ears were 16 and 7 dB HL, respectively, within clinically-defined normal limits. In contrast, the intensity threshold for monaural loudness discrimination at 1 kHz was 6.5±2.1 dB in the left ear and 6.5±1.9 dB in the right ear at 40 dB sensation level, well above the means of the control population (left ear: 1.6±0.22 dB; right ear: 1.7±0.19 dB). The results indicate that auditory cortex lowers just-noticeable differences for loudness discrimination by approximately 5 dB but is not necessary for tone detection in quiet. Previous human and Old-world monkey experiments employing lesion-effect, neurophysiology, and neuroimaging methods to investigate the role of auditory cortex in intensity processing are reviewed.
登录
查看更多内容
影响因子：
25
作者：
Jaramillo, Santiago;Zador, Anthony M.
通讯作者：
Zador, Anthony M.
影响因子：
2.4
作者：
Hall, DA;Haggard, MP;Bowtell, RW
通讯作者：
Bowtell, RW
影响因子：
5.7
作者：
Bilecen, D;Seifritz, E;Schulte, AC
通讯作者：
Schulte, AC
影响因子：
1.2
作者：
Baran, Jane A;Bothfeldt, Richard W;Musiek, Frank E
通讯作者：
Musiek, Frank E
影响因子：
24.8
作者：
MASTERTON, RB;BERKLEY, MA
通讯作者：
BERKLEY, MA