The auditory cortex mediates the perceptual effects of acoustic temporal expectation.

The auditory cortex mediates the perceptual effects of acoustic temporal expectation.
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DOI:
10.1038/nn.2688
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发表时间:
2011-02
影响因子:
25
通讯作者:
Zador, Anthony M.
Zador, Anthony M.
中科院分区:
医学1区
文献类型:
--
作者:
Jaramillo, Santiago;Zador, Anthony M.

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当事件发生在可预测的时刻时,预测可以提高性能。对事件发生时间的了解可以调节运动神经回路,提高反应速度。相比之下,神经元机制的变化,在感官知觉由于预期没有得到很好的理解。我们已经为大鼠开发了一种新的行为模式,在这种模式中,我们操纵了对声音时机的期望。有效的期望提高了受试者表现的速度和准确性,这不仅表明运动准备得到了改善,而且还增强了感知。初级听觉皮层的单神经元记录显示,在期望值提高的时期,声音的表征增强。此外,我们发现听觉皮层的活动与任务的表现有因果关系,并且神经元对声音的表征的变化可以在逐个试验的基础上预测性能。我们的研究结果表明,早在初级感觉皮层的神经元表征的变化介导的时间期望所赋予的感知优势。
When events occur at predictable instants, anticipation improves performance. Knowledge of event timing modulates motor circuits, improving response speed. By contrast, the neuronal mechanisms underlying changes in sensory perception due to expectation are not well understood. We have developed a novel behavioral paradigm for rats in which we manipulated expectations about sound timing. Valid expectations improved both the speed and the accuracy of subjects’ performance, indicating not only improved motor preparedness but also enhanced perception. Single neuron recordings in primary auditory cortex revealed enhanced representation of sounds during periods of heightened expectation. Furthermore, we found that activity in auditory cortex was causally linked to the performance of the task, and that changes in the neuronal representation of sounds predicted performance on a trial-by-trial basis. Our results indicate that changes in neuronal representation as early as primary sensory cortex mediate the perceptual advantage conferred by temporal expectation.
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