Revealing neuronal function through microelectrode array recordings.

Revealing neuronal function through microelectrode array recordings.
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DOI:
10.3389/fnins.2014.00423
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发表时间:
2014
影响因子:
4.3
通讯作者:
Frey U
Frey U
中科院分区:
医学2区
文献类型:
--
作者:
Obien ME;Deligkaris K;Bullmann T;Bakkum DJ;Frey U

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微电极阵列和微探针已被广泛用于在体外和体内测量神经元活动。其关键优势是能够同时记录和刺激多个部位的神经元。然而,与细胞内记录的单细胞或单通道分辨率不同,微电极检测来自每个传感器周围所有可能来源的信号。在这里,我们回顾了目前对微电极信号的理解和分析它们的技术。我们介绍了微电极技术的不断进步,重点是通过与片上电路的单片集成实现更高的分辨率和记录质量。我们展示了最近先进的微电极阵列测量方法如何促进对单个神经元和网络功能的理解。
Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously. However, unlike the single-cell or single-channel resolution of intracellular recording, microelectrodes detect signals from all possible sources around every sensor. Here, we review the current understanding of microelectrode signals and the techniques for analyzing them. We introduce the ongoing advancements in microelectrode technology, with focus on achieving higher resolution and quality of recordings by means of monolithic integration with on-chip circuitry. We show how recent advanced microelectrode array measurement methods facilitate the understanding of single neurons as well as network function.
从分子到全脑网络的睡眠,可塑性和记忆力。
DOI: 10.1016/j.cub.2013.07.025
发表时间: 2013-09-09
期刊: CURRENT BIOLOGY
影响因子: 9.2
作者:
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