Revealing neuronal function through microelectrode array recordings.
Revealing neuronal function through microelectrode array recordings.
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DOI:
10.3389/fnins.2014.00423
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发表时间:
2014
影响因子:
4.3
通讯作者:
Frey U
中科院分区:
文献类型:
--
作者:
Obien ME;Deligkaris K;Bullmann T;Bakkum DJ;Frey U
Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously. However, unlike the single-cell or single-channel resolution of intracellular recording, microelectrodes detect signals from all possible sources around every sensor. Here, we review the current understanding of microelectrode signals and the techniques for analyzing them. We introduce the ongoing advancements in microelectrode technology, with focus on achieving higher resolution and quality of recordings by means of monolithic integration with on-chip circuitry. We show how recent advanced microelectrode array measurement methods facilitate the understanding of single neurons as well as network function.
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