FLASH radiotherapy and the associated dosimetric challenges
FLASH radiotherapy and the associated dosimetric challenges
复制标题
闪光放射治疗和相关的剂量测定挑战
DOI：
10.1088/1742-6596/2630/1/012010
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ceberg S
中科院分区：
文献类型：
--
作者：
Ceberg S
在瑞典隆德的隆德大学和Skåne大学医院，作为第一家诊所，我们修改了临床Elekta Precise直线加速器，用于超高剂量率（FLASH）照射的可转换输送。而最近发表的评论强调，需要标准化的协议，超高剂量率束剂量测定，以能够确定真正的潜力闪光照射，几个剂量研究以及在体外和体内实验已经在我们的单位进行。使用辐射变色胶片和热发光剂量计，建立了验证FLASH照射对细胞培养物、斑马鱼胚胎和小动物的准确剂量传递的剂量测定程序。此外，最近发表了在我们的临床环境中对犬患者进行电子闪光放射治疗（FLASH-RT）的首次经验。我们的研究设施还包括一个3D聚合物凝胶制造实验室。最近，我们开始研究NIPAM聚合物凝胶剂量计用于超高剂量率剂量测量的可行性。此外，在改进的Elekta直线加速器的掩体中，可以使用表面引导放射治疗（SGRT）系统。Catalyst™系统（C-Rad Positioning，Uppsala，Sweden）为患者设置、实时运动监测和呼吸适应性治疗提供光学表面成像。为了使用超高剂量率治疗患者，实时验证射束和目标之间的对准至关重要，因为剂量在几分之一秒内输送。我们的研究小组在过去十年中研究和开发了SGRT工作流程，改善了几个癌症患者群体的患者设置和呼吸适应性治疗。最近，我们也开始调查的可行性，一个实时运动监测系统的表面引导FLASH-RT。这两个FLASH相关的研究，三维聚合物凝胶剂量测定和表面引导FLASH-RT是我们所知的第一种。在介绍了FLASH领域和相关的剂量学挑战之后，我们在这里的目的是介绍两项正在进行的研究，包括一些初步结果。
At Lund University and Skåne University Hospital in Lund, Sweden, we have, as the first clinic, modified a clinical Elekta Precise linear accelerator for convertible delivery of ultra-high dose rate (FLASH) irradiation. Whereas recently published reviews highlighted the need for standardised protocols for ultra-high dose rate beam dosimetry to be able to determine the true potential of FLASH irradiation, several dosimetry studies as well as in-vitro and in-vivo experiments have been carried out at our unit. Dosimetric procedures for verification of accurate dose delivery of FLASH irradiation to cell cultures, zebrafish embryos and small animals have been established using radiochromic films and thermo-luminescent dosimeters. Also, recently the first experience of electron FLASH radiotherapy (FLASH-RT) in canine patients in our clinical setting was published. Our research facilities also include a laboratory for 3D polymer gel manufacturing. Recently, we started investigating the feasibility of a NIPAM polymer gel dosimeter for ultra-high dose rate dosimetry. Furthermore, in the bunker of the modified Elekta linear accelerator, a Surface Guided Radiotherapy (SGRT) system is accessible. The Catalyst™ system (C-Rad Positioning, Uppsala, Sweden) provides optical surface imaging for patient setup, real-time motion monitoring and breathing adapted treatment. Aiming at treating patients using ultra-high dose rates, a real-time validation of the alignment between the beam and the target is crucial as the dose is delivered in a fraction of a second. Our research group has during the last decade investigated and developed SGRT workflows which improved patient setup and breathing adapted treatment for several cancer patient groups. Recently, we also started investigating the feasibility of a real-time motion monitoring system for surface guided FLASH-RT. Both FLASH related studies; 3D polymer gel dosimetry and surface guided FLASH-RT are to our knowledge the first of their kind. Following an introduction to the field of FLASH and the associated dosimetric challenges, we here aim to present the two ongoing studies including some preliminary results.
登录
查看更多内容
影响因子：
3.8
作者：
Romano, Francesco;Bailat, Claude;Jorge, Patrik Goncalves;Lerch, Michael Lloyd Franz;Darafsheh, Arash
通讯作者：
Darafsheh, Arash
影响因子：
3.8
作者：
Al-Hallaq, Hania A.;Cervino, Laura;Gutierrez, Alonso N.;Havnen-Smith, Amanda;Higgins, Susan A.;Kugele, Malin;Padilla, Laura;Pawlicki, Todd;Remmes, Nicholas;Smith, Koren;Tang, Xiaoli;Tome, Wolfgang A.
通讯作者：
Tome, Wolfgang A.
影响因子：
3.8
作者：
Gomez, Faustino;Gonzalez-Castano, Diego M.;Gomez Fernandez, Nicolas;Pardo-Montero, Juan;Schueller, Andreas;Gasparini, Alessia;Vanreusel, Verdi;Verellen, Dirk;Felici, Giuseppe;Kranzer, Rafael;Paz-Martin, Jose
通讯作者：
Paz-Martin, Jose
影响因子：
3.5
作者：
Ceberg, Sofie;Gagne, Isabelle;Back, Sven A. J.
通讯作者：
Back, Sven A. J.
影响因子：
2.1
作者：
Kügele M;Edvardsson A;Berg L;Alkner S;Andersson Ljus C;Ceberg S
通讯作者：
Ceberg S