Lung cancer screening with low-dose computed tomography.
Lung cancer screening with low-dose computed tomography.
复制标题
使用低剂量计算机断层扫描进行肺癌筛查。
DOI：
10.1016/j.rcl.2013.08.006
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发表时间：
2014-01
影响因子：
1.9
通讯作者：
Chiles, Caroline
中科院分区：
文献类型：
--
作者：
Chiles, Caroline
NLST结果的公布表明，在高危人群中，LDCT筛查可使肺癌特异性死亡率降低20%，这标志着肺癌筛查的一个转折点。这是一项随机对照试验首次显示，采用早期检测肺癌的成像方式可以降低死亡率。目前的指南支持对年龄在55 - 74岁、吸烟史至少30包年的吸烟者和前吸烟者进行LDCT筛查。强烈鼓励遵循已发表的结节随访算法。筛查研究的未来方向包括筛查人群的风险分层选择，以及对不确定肺结节的诊断随访的改进。与筛查其他恶性肿瘤一样，LDCT筛查肺癌显示，有些惰性肺癌可能不会致命。如果我们要最大化肺癌筛查的风险-收益比，还需要更多的研究。
The announcement of the results of the NLST, showing a 20% reduction in lung-cancer specific mortality with LDCT screening in a high risk population, marked a turning point in lung cancer screening. This was the first time that a randomized controlled trial had shown a mortality reduction with an imaging modality aimed at early detection of lung cancer. Current guidelines endorse LDCT screening for smokers and former smokers ages 55 to 74, with at least a 30 pack year smoking history. Adherence to published algorithms for nodule follow-up is strongly encouraged. Future directions for screening research include risk stratification for selection of the screening population, and improvements in the diagnostic follow-up for indeterminate pulmonary nodules. As with screening for other malignancies, screening for lung cancer with LDCT has revealed that there are indolent lung cancers which may not be fatal. More research is necessary if we are to maximize the risk-benefit ratio in lung cancer screening.
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影响因子：
10
作者：
Ashraf, H.;Tonnesen, P.;Dossing, M.
通讯作者：
Dossing, M.
影响因子：
10.3
作者：
Aberle, Denise R.;Adams, Amanda M.;Pinsky, Paul F.
通讯作者：
Pinsky, Paul F.
影响因子：
158.5
作者：
Bleyer, Archie;Welch, H. Gilbert
通讯作者：
Welch, H. Gilbert
影响因子：
1.3
作者：
Funama, Yoshinori;Awai, Kazuo;Yamashita, Yasuyuki
通讯作者：
Yamashita, Yasuyuki
DOI：
10.1001/jama.1958.02990030008003
发表时间：
1958-01-01
影响因子：
120.7
作者：
GOOD, CA;WILSON, TW
通讯作者：
WILSON, TW