The Association between Total Genotype Score and Athletic Performance in Weightlifters.
The Association between Total Genotype Score and Athletic Performance in Weightlifters.
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DOI：
10.3390/genes13112091
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发表时间：
2022-11-10
期刊：
影响因子：
3.5
通讯作者：
Kikuchi, Naoki
中科院分区：
文献类型：
--
作者：
Homma, Hiroki;Saito, Mika;Saito, Aoto;Kozuma, Ayumu;Matsumoto, Ryutaro;Matsumoto, Shingo;Kobatake, Naoyuki;Okamoto, Takanobu;Nakazato, Koichi;Nishiyama, Tetsunari;Kikuchi, Naoki
关键词：
本研究旨在探讨力量取向遗传多态性与举重运动状态之间的关系，建立总基因型评分（TGS），并验证TGS模型与力量取向运动员之间的相关性。首先，研究人员对192名举重运动员和416名对照者进行了研究，并使用TaqMan SNP基因分型试验对之前与力量、力量状态和表型相关的12种多态性进行了基因分型。基于病例对照研究，我们使用PWM（功率导向整体模型）计算了12个多态性的TGS，使用WRM（举重相关模型）计算了其中6个多态性的TGS。其次，比较了177名力量和力量运动员和416名对照组的WRM TGS。举重运动员和对照组之间的PWM评分没有显著差异。举重运动员和优秀举重运动员的WRM得分高于对照组。然而，WRM得分与举重成绩无关。在力量导向运动员和控制组之间，WRM没有显著差异。我们的研究能够基于病例对照结果为举重运动员创建TGS模型。然而，TGS模型并不适用于其他力量型运动员。
This study aimed to investigate the relationship between power-oriented genetic polymorphisms and weightlifting status, create a total genotype score (TGS), and validate the association between TGS models and power-oriented athletes. First, 192 weightlifters and 416 controls were studied, and 12 polymorphisms that have previously been associated with strength, power status, and phenotype were genotyped using the TaqMan SNP genotyping assay. We calculated the TGS for the 12 polymorphisms using a PWM (power-oriented whole model) and for 6 of them using a WRM (weightlifting-related model) based on a case–control study. Second, the TGS of the WRM was compared for 177 strength and power athletes and 416 controls. There was no significant difference in the PWM score between weightlifters and the controls. Weightlifters and elite weightlifters had higher WRM scores than the controls. However, the WRM score had no association with weightlifting performance. There was no significant difference in the WRM between power-oriented athletes and the controls. Our study was able to create a TGS model for weightlifters based on case–control results. However, the TGS model could not be applied to other power-oriented athletes.
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影响因子：
5.6
作者：
Gineviciene V;Jakaitiene A;Aksenov MO;Aksenova AV;Druzhevskaya AM;Astratenkova IV;Egorova ES;Gabdrakhmanova LJ;Tubelis L;Kucinskas V;Utkus A
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影响因子：
5.6
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影响因子：
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影响因子：
3.3
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通讯作者：
Lucia, Alejandro
影响因子：
4.8
作者：
Handschin, Christoph;Chin, Sherry;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.