Bacterial and eukaryotic systems collide in the three Rs of Methanococcus.

Bacterial and eukaryotic systems collide in the three Rs of Methanococcus.
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细菌和真核系统在甲烷球菌的三个 R 中发生碰撞。

DOI:
10.1042/bst0390111
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发表时间:
2011
影响因子:
3.9
通讯作者:
Parker RP
Parker RP
中科院分区:
生物学3区
文献类型:
--
作者:
Parker RP

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海沼甲烷球菌S2是一种具有发达遗传系统的产甲烷古菌。它的嗜温性质提供了一个简单的系统,在其中使用细菌和真核基因进行互补。虽然古细菌的信息处理系统通常与真核生物的信息处理系统比细菌的信息处理系统更相似,但甲烷球菌目具有独特的DNA复制蛋白,具有多个MCM(微型染色体维持)蛋白,并且没有明显的originbinding蛋白。M.重组和修复蛋白同源物的寻找。maripaludishas揭示了细菌、真核生物和某些古细菌特异性同源物的混合物。一些修复途径似乎完全不存在,但古细菌特异性蛋白可能具有这些功能。对M. maripaludisare是真核生物和细菌同源物的有趣混合物,并且可以提供用于揭示来自不同生命领域的蛋白质之间的新颖相互作用的系统。
Methanococcus maripaludisS2 is a methanogenic archaeon with a well-developed genetic system. Its mesophilic nature offers a simple system in which to perform complementation using bacterial and eukaryotic genes. Although information-processing systems in archaea are generally more similar to those in eukaryotes than those in bacteria, the order Methanococcales has a unique complement of DNA replication proteins, with multiple MCM (minichromosome maintenance) proteins and no obvious originbinding protein. A search for homologues of recombination and repair proteins inM. maripaludishas revealed a mixture of bacterial, eukaryotic and some archaeal-specific homologues. Some repair pathways appear to be completely absent, but it is possible that archaeal-specific proteins could carry out these functions. The replication, recombination and repair systems inM. maripaludisare an interesting mixture of eukaryotic and bacterial homologues and could provide a system for uncovering novel interactions between proteins from different domains of life.
马里帕鲁迪斯甲烷球菌:具有多种功能 MCM 蛋白的古细菌?
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