A systematic review of the prevalence of schizophrenia.
A systematic review of the prevalence of schizophrenia.
复制标题
DOI：
10.1371/journal.pmed.0020141
复制
发表时间：
2005-05
期刊：
影响因子：
15.8
通讯作者：
McGrath, J
中科院分区：
文献类型：
--
作者：
Saha, S;Chant, D;Welham, J;McGrath, J
了解精神分裂症的患病率对卫生服务规划和危险因素流行病学都有重要意义。本综述的目的是系统地识别和整理描述精神分裂症患病率的研究，总结这些研究的结果，并探索可能影响患病率估计的选定因素。通过搜索电子数据库、审查引文和给作者写信来确定与精神分裂症患病率相关的原始数据的研究(发表于1965-2002年)。这些研究分为“核心”研究、“移民”研究和以“其他特殊群体”为基础的研究。为了确定离散的患病率估计，研究之间和研究内的过滤器被应用。根据流行类型(点、期、终生和终生患病风险)对基础估计值进行分类时，绘制患病率估计值的累积曲线图并描述其分布。在综合患病率估计的基础上，检查了选定的关键变量(性别、城市化、流动人口状况、国家经济指数和研究质量)的影响。188项研究共确定了1721个患病率估计值。这些估计来自46个国家，并基于估计的154,140个可能重叠的流行病例。我们确定了132项核心研究，15项移民研究，41项基于其他特殊群体的研究。每千人患病风险分布的中位数分别为4.6(1.9-10.0)、3.3(1.3-8.2)、4.0(1.6-12.1)和7.2(3.1-27.1)。基于综合患病率估计，我们发现(A)男性和女性之间没有显著差异，或者(B)城市、农村和混合地点之间没有显著差异。与本地出生的人相比，流动人口中精神分裂症的患病率更高：流动人口与本地出生的比率中位数(10%-90%分位数)为1.8(0.9-6.4)。当地点按经济状况分组时，来自“最不发达”国家的患病率估计值显著低于来自“新兴”和“发达”地点的估计患病率(p=0.04)。质量得分越高的研究，患病率估计值就越高(p=0.02)。有大量关于精神分裂症患病率的数据。这些梯度，以及在流行率估计分布中发现的可变性，可以为未来以假设为导向的研究提供方向。对1965年至2002年间发表的188项研究的分析表明，男性和女性之间没有差异，并表明目前教科书中对终身患病风险的估计太高了。
Understanding the prevalence of schizophrenia has important implications for both health service planning and risk factor epidemiology. The aims of this review are to systematically identify and collate studies describing the prevalence of schizophrenia, to summarize the findings of these studies, and to explore selected factors that may influence prevalence estimates. Studies with original data related to the prevalence of schizophrenia (published 1965–2002) were identified via searching electronic databases, reviewing citations, and writing to authors. These studies were divided into “core” studies, “migrant” studies, and studies based on “other special groups.” Between- and within-study filters were applied in order to identify discrete prevalence estimates. Cumulative plots of prevalence estimates were made and the distributions described when the underlying estimates were sorted according to prevalence type (point, period, lifetime, and lifetime morbid risk). Based on combined prevalence estimates, the influence of selected key variables was examined (sex, urbanicity, migrant status, country economic index, and study quality). A total of 1,721 prevalence estimates from 188 studies were identified. These estimates were drawn from 46 countries, and were based on an estimated 154,140 potentially overlapping prevalent cases. We identified 132 core studies, 15 migrant studies, and 41 studies based on other special groups. The median values per 1,000 persons (10%–90% quantiles) for the distributions for point, period, lifetime, and lifetime morbid risk were 4.6 (1.9–10.0), 3.3 (1.3–8.2), 4.0 (1.6–12.1), and 7.2 (3.1–27.1), respectively. Based on combined prevalence estimates, we found no significant difference (a) between males and females, or (b) between urban, rural, and mixed sites. The prevalence of schizophrenia in migrants was higher compared to native-born individuals: the migrant-to-native-born ratio median (10%–90% quantile) was 1.8 (0.9–6.4). When sites were grouped by economic status, prevalence estimates from “least developed” countries were significantly lower than those from both “emerging” and “developed” sites (p = 0.04). Studies that scored higher on a quality score had significantly higher prevalence estimates (p = 0.02). There is a wealth of data about the prevalence of schizophrenia. These gradients, and the variability found in prevalence estimate distributions, can provide direction for future hypothesis-driven research. Analysis of 188 studies published between 1965 to 2002 yields no difference between men and women and suggests that current text-book estimates for lifetime morbid risk are too high.
登录
查看更多内容
影响因子：
6.7
作者：
Awas, M;Kebede, D;Alem, A
通讯作者：
Alem, A
影响因子：
10.5
作者：
BENTOVIM, DI;CUSHNIE, JM
通讯作者：
CUSHNIE, JM
影响因子：
6.7
作者：
BOLLERUP, TR
通讯作者：
BOLLERUP, TR
影响因子：
--
作者：
Aleman, A;Kahn, RS;Selten, JP
通讯作者：
Selten, JP
影响因子：
6.7
作者：
ASTRUP, C
通讯作者：
ASTRUP, C