Systemic inflammation, enteropathogenic E. Coli, and micronutrient insufficiencies in the first trimester as possible predictors of preterm birth in rural Bangladesh: a prospective study.
Systemic inflammation, enteropathogenic E. Coli, and micronutrient insufficiencies in the first trimester as possible predictors of preterm birth in rural Bangladesh: a prospective study.
复制标题
孟加拉国农村地区早产期的全身性炎症，肠病大肠杆菌和微量营养素不足，可能是早产的预测指标：一项前瞻性研究。
DOI：
10.1186/s12884-024-06266-9
复制
发表时间：
2024-01-24
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
--
作者：
An incomplete understanding of preterm birth is especially concerning for low-middle income countries, where preterm birth has poorer prognoses. While systemic proinflammatory processes are a reportedly normal component of gestation, excessive inflammation has been demonstrated as a risk factor for preterm birth. There is minimal research on the impact of excessive maternal inflammation in the first trimester on the risk of preterm birth in low-middle income countries specifically. Pregnant women were enrolled at the rural Bangladesh site of the National Institute of Child Health Global Network Maternal Newborn Health Registry. Serum samples were collected to measure concentrations of the inflammatory markers C-reactive protein (CRP) and Alpha-1-acid glycoprotein (AGP), and stool samples were collected and analyzed for enteropathogens. We examined associations of maternal markers in the first-trimester with preterm birth using logistic regression models. CRP and AGP were primarily modeled with a composite inflammation predictor. Out of 376 singleton births analyzed, 12.5% were preterm. First trimester inflammation was observed in 58.8% of all births, and was significantly associated with increased odds of preterm birth (adjusted odds ratio [aOR] = 2.23; 95% confidence interval [CI]: 1.03, 5.16), independent of anemia. Maternal vitamin B12 insufficiency (aOR = 3.33; 95% CI: 1.29, 8.21) and maternal anemia (aOR = 2.56; 95% CI: 1.26, 5.17) were also associated with higher odds of preterm birth. Atypical enteropathogenic E. coli detection showed a significant association with elevated AGP levels and was significantly associated with preterm birth (odds ratio [OR] = 2.36; 95% CI: 1.21, 4.57), but not associated with CRP. Inflammation, anemia, and vitamin B12 insufficiency in the first trimester were significantly associated with preterm birth in our cohort from rural Bangladesh. Inflammation and anemia were independent predictors of premature birth in this low-middle income setting where inflammation during gestation was widespread. Further research is needed to identify if infections such as enteropathogenic E. coli are a cause of inflammation in the first trimester, and if intervention for infection would decrease preterm birth.
登录
查看更多内容
影响因子：
5.5
作者：
Khalil I;Walker R;Porter CK;Muhib F;Chilengi R;Cravioto A;Guerrant R;Svennerholm AM;Qadri F;Baqar S;Kosek M;Kang G;Lanata C;Armah G;Wierzba T;Hasso-Agopsowicz M;Giersing B;Louis Bourgeois A
通讯作者：
Louis Bourgeois A
影响因子：
13.8
作者：
Gao R;Liu B;Yang W;Wu Y;Wang B;Santillan MK;Ryckman K;Santillan DA;Bao W
通讯作者：
Bao W
影响因子：
9
作者：
Green ES;Arck PC
通讯作者：
Arck PC
影响因子：
4.7
作者：
通讯作者：
--
DOI：
10.3109/14767058.2012.671872
发表时间：
2012-10-01
影响因子：
1.8
作者：
Kessous, Roy;Weintraub, Adi Y.;Sheiner, Eyal
通讯作者：
Sheiner, Eyal