Tissue-engineered lymphatic graft for the treatment of lymphedema.
Tissue-engineered lymphatic graft for the treatment of lymphedema.
复制标题
用于治疗淋巴水肿的组织工程淋巴移植物。
DOI：
10.1016/j.jss.2014.07.059
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Seifalian,AlexanderM
中科院分区：
文献类型：
--
作者：
Kanapathy,Muholan;Patel,NikhilM;Kalaskar,DeepakM;Mosahebi,Afshin;Mehrara,BabakJ;Seifalian,AlexanderM
背景淋巴水肿是一种慢性疾病，目前尚无有效的治疗方法，随着淋巴管移植重建受损集合淋巴管的出现，结合细胞成分、支架材料和分子信号的组织工程方法在继发性淋巴水肿的治疗中具有巨大的潜力。本文综述了淋巴管移植物的理想特性、局限性和面临的挑战，以及开发组织工程化淋巴管移植物的方法。MethodsLiterature on tissue engineering of lymphatic system and lymphatic tissue biologywas reviewed.ResultsThe prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves.需要合适的支架材料以确保构建体的稳定性和功能性。构建体的内皮化可以通过生物功能化和纳米形貌学来增强，其模拟细胞外基质。纳米复合聚合物与现有的生物材料的性能得到改善，有可能有利于淋巴graft.ConclusionsWith组织工程的深入了解，纳米技术，和淋巴再生的生物学知识的提高，发展成功的淋巴移植的愿望是可以实现的。
BackgroundLymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.MethodsLiterature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.ResultsThe prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.ConclusionsWith the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.
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